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Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00357864
Recruitment Status : Completed
First Posted : July 28, 2006
Last Update Posted : August 30, 2007
Sponsor:
Information provided by:
Danish Headache Center

Study Description
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Brief Summary:
To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Condition or disease Intervention/treatment
Headache Drug: carbachol

Detailed Description:

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)

Study Design
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Study Type : Observational
Actual Enrollment : 15 participants
Time Perspective: Prospective
Official Title: Basic Research on Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow in a Humane Experimental Headache Model
Study Start Date : July 2006
Actual Study Completion Date : April 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Headache
Drug Information available for: Carbachol

Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy volunteers
  • Aged 18-40
  • 50-100 kg
  • Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria:

  • Tension type headache more than once/month
  • Other primary headaches
  • Daily medication except contraceptives
  • Drug taken within 4 times the halflife for the specific drug except contraceptives
  • Pregnant or lactating women
  • Exposure to radiation within the last year
  • Headache within the last 24 hours before start of trial
  • Hypertension
  • Hypotension
  • Respiratory or cardiac disease
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00357864


Locations
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Denmark
Dansih Headache Center
Glostrup, Denmark, 2600
Sponsors and Collaborators
Danish Headache Center
Investigators
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Principal Investigator: henrik schytz Danish Headache Center
More Information
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ClinicalTrials.gov Identifier: NCT00357864    
Other Study ID Numbers: 2006-002462-19
First Posted: July 28, 2006    Key Record Dates
Last Update Posted: August 30, 2007
Last Verified: August 2007
Additional relevant MeSH terms:
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Headache
Pain
Neurologic Manifestations
Carbachol
Cardiotonic Agents
Miotics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
 Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Protective Agents