NASPI: N-Acetylcysteine vs. Ascorbic Acid for Prevention of Contrast Induced Nephropathy in Renal Insufficiency Undergoing Coronary Catheterization
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The contrast induced nephropathy (CIN) has been known to be associated with significant clinical and economic consequences. Many studies were performed to find the pathophysiology and preventive measures for CIN. But the results were somewhat frustrating. Recently, it has been reported that the N-acetylcysteine and ascorbic acid might have preventive effects for CIN by their antioxidant effects.There have been no study to compare these two antioxidant.
Condition or disease
Drug: N-acetylcysteinDrug: ascorbic acid
N-acetylcysteine and ascorbic acid may prevent the CIN in the patients with underlying renal insufficiency who is undergoing the coronary angiography. The effect may derive from the antioxidant function of these two antioxidant. We studied to find which of the two antioxidants is more beneficial in prevention of CIN
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Ages Eligible for Study:
19 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Stable Angina pectoris patients
Patients who required the coronary catheterization
Creatinine clearance rates =<60 mL/min using the Cockcroft-Gault formula
Age of 19 or over 19
Having received contrast media within 7 days of study entry
Emergent coronary angiography
Acute renal failure
End-stage renal disease requiring dialysis
History of hypersensitivity reaction to contrast media
Parenteral use of diuretics
Recent use of N-acetylcysteine
Recent use of Ascorbic acid
Recent use of statin
Use of metformin or nonsteroidal anti-inflammatory drugs within 48 hours of the procedure.