Genetics of Progressive Multifocal Leukoencephalopathy and Acquired Immunodeficiency Syndrome
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ClinicalTrials.gov Identifier: NCT00342602 |
Recruitment Status :
Completed
First Posted : June 21, 2006
Last Update Posted : March 17, 2009
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This study will identify genetic factors associated with the development of progressive multifocal leukoencephalopathy (PML) in patients with acquired immunodeficiency syndrome (AIDS). PML is a life-threatening infection of the brain that affects about 5 percent of untreated patients with AIDS. Its symptoms include mental deterioration, vision loss, speech disturbances, ataxia (inability to coordinate movements), paralysis, and coma. PML is caused by a polyomavirus called the JC virus.
It is estimated that up to 80 percent of the human population has been exposed to the JC virus, but the disease is very rare. The virus only becomes active in people who have compromised immune systems, such as those undergoing immune suppressive chemotherapy for cancer and those with damaged immune systems due to HIV.
Patients who have participated in the Multicenter AIDS Cohort Study may be eligible for this study, as well as healthy normal volunteers who will serve as controls. The study will review clinical information from patients and analyze genetic factors from both patients and control subjects to investigate genes associated with AIDS and JC virus infection.
Condition or disease |
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PML AIDS |
Study Type : | Observational |
Enrollment : | 450 participants |
Official Title: | Influence of Host Genetic Factors in Development of PML in an AIDS Cohort |
Study Start Date : | August 2005 |

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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
- No available subjects will be excluded.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00342602
United States, California | |
University of California, Los Angeles | |
Los Angeles, California, United States, 90095 | |
United States, Illinois | |
Northwestern University | |
Chicago, Illinois, United States, 60611 | |
John H. Stroger, Jr. Hospital of Cook County | |
Chicago, Illinois, United States, 60612 | |
Howard Brown Health Center | |
Chicago, Illinois, United States, 60613 | |
United States, Maryland | |
Johns Hopskins Hospital | |
Baltimore, Maryland, United States, 21205 | |
United States, Pennsylvania | |
University of Pittsburgh | |
Pittsburgh, Pennsylvania, United States, 15261 |
Publications:
ClinicalTrials.gov Identifier: | NCT00342602 History of Changes |
Other Study ID Numbers: |
999905218 05-C-N218 |
First Posted: | June 21, 2006 Key Record Dates |
Last Update Posted: | March 17, 2009 |
Last Verified: | June 2006 |
Keywords provided by National Institutes of Health Clinical Center (CC):
JC Virus Opportunistic Infection Single Nucleotide Polymorphism Genotype Sequencing |
Additional relevant MeSH terms:
Acquired Immunodeficiency Syndrome HIV Infections Leukoencephalopathy, Progressive Multifocal Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Slow Virus Diseases Immunologic Deficiency Syndromes Immune System Diseases |
Encephalitis, Viral Central Nervous System Viral Diseases Polyomavirus Infections DNA Virus Infections Infectious Encephalitis Encephalitis Brain Diseases Central Nervous System Diseases Nervous System Diseases Leukoencephalopathies Central Nervous System Infections Demyelinating Diseases |