Genetics of Progressive Multifocal Leukoencephalopathy and Acquired Immunodeficiency Syndrome
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00342602|
Recruitment Status : Completed
First Posted : June 21, 2006
Last Update Posted : March 17, 2009
This study will identify genetic factors associated with the development of progressive multifocal leukoencephalopathy (PML) in patients with acquired immunodeficiency syndrome (AIDS). PML is a life-threatening infection of the brain that affects about 5 percent of untreated patients with AIDS. Its symptoms include mental deterioration, vision loss, speech disturbances, ataxia (inability to coordinate movements), paralysis, and coma. PML is caused by a polyomavirus called the JC virus.
It is estimated that up to 80 percent of the human population has been exposed to the JC virus, but the disease is very rare. The virus only becomes active in people who have compromised immune systems, such as those undergoing immune suppressive chemotherapy for cancer and those with damaged immune systems due to HIV.
Patients who have participated in the Multicenter AIDS Cohort Study may be eligible for this study, as well as healthy normal volunteers who will serve as controls. The study will review clinical information from patients and analyze genetic factors from both patients and control subjects to investigate genes associated with AIDS and JC virus infection.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||450 participants|
|Official Title:||Influence of Host Genetic Factors in Development of PML in an AIDS Cohort|
|Study Start Date :||August 2005|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00342602
|United States, California|
|University of California, Los Angeles|
|Los Angeles, California, United States, 90095|
|United States, Illinois|
|Chicago, Illinois, United States, 60611|
|John H. Stroger, Jr. Hospital of Cook County|
|Chicago, Illinois, United States, 60612|
|Howard Brown Health Center|
|Chicago, Illinois, United States, 60613|
|United States, Maryland|
|Johns Hopskins Hospital|
|Baltimore, Maryland, United States, 21205|
|United States, Pennsylvania|
|University of Pittsburgh|
|Pittsburgh, Pennsylvania, United States, 15261|