Clinical Study on Optimised Removal of Protein-bound Uremic Toxins With Convective Dialysis Treatment.
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Patients will be treated with hemodiafiltration (HDF) in postdilution mode, as a control therapy, during 9 weeks. During week 5 the 1st intervention treatment, predilution hemofiltration (HF) or predilution HDF, will be performed as a midweek session. After 4 additional weeks of control therapy the other intervention treatment will be performed. Samples will be taken during week 4, 5 and 9: from inlet blood flow (0, 30, 60, 120 and 240 min), from outlet blood flow and dialysate outflow (30, 60, 120 and 240 min).
Condition or disease
Chronic Renal Failure
Procedure: Performance of predilution hemofiltration, predilution hemodiafiltration or postdilution hemodiafiltration
To evaluate what is more effective for convective removal of protein-bound solutes - predilution or postdilution of blood? [ Time Frame: Samples taken at week 4, 5 and 9. Bloodsamples taken at 0, 30, 60, 120 and 240 min. Dialysate taken at 30, 60, 120 and 240 min. ]
To check which respective roles diffusion and convection play in the removal of protein-bound uremic toxins? [ Time Frame: Samples taken at week 4, 5 and 9. Bloodsamples taken at 0, 30, 60, 120 and 240 min. Dialysate taken at 30, 60, 120 and 240 min. ]
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Ages Eligible for Study:
18 Years to 85 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
stable on hemodialysis >= 6 months
of which presently on high-flux HD >= 1 month
18 years < age < 85 years
blood flow rate >= 300ml/min
expected survival < 1 year
expected transplant within < 1 year
chronic inflammation condition
treated with single needle dialysis
presently treated with hemodiafiltration or low-flux hemodiafiltration