Chemoradiation and Endothelial Progenitor Cells in Colorectal Cancer
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|ClinicalTrials.gov Identifier: NCT00325871|
Recruitment Status : Completed
First Posted : May 15, 2006
Last Update Posted : March 22, 2017
Colorectal cancer (CRC) is one of the common malignancies worldwide, accounting for a significant percentage of cancer mortality. Concurrent chemoradiation (CCRT) is now a standard treatment for unresectable malignancies of anorectum. To improve quality of life, CCRT is also commonly applied in treatment of lower rectal and anal canal cancer to preserve anal sphincter function. The most commonly used chemotherapeutic drugs combined with radiation as radiosensitizers is 5-fluorouracil (5-FU). Circulating endothelial progenitor cells (EPC), which contribute to the tumor vessel formation, reflect the response to chemotherapy both in animal model and clinical trial. Thus, circulating EPC can be used as a marker for optimizing and monitoring the anti-angiogenesis therapy including angiogenesis inhibitors and chemotherapy. Whether circulating EPC can be served as a marker of CCRT efficacy or not remains undetermined. Since CCRT is now a standard treatment of locally advanced and high-risk CRC, the development of a surrogate marker for monitoring CCRT response and optimize treatment intensity is very important.
In this grant we intent to monitor the levels of circulating EPC in locally advanced and high-risk CRC patients before, during and after CCRT. To further characterize the changes in function and biology of EPC caused by CCRT, a syngeneic animal model will be also used to evaluate the clonogenecity and specific gene expression of EPC in tumor-bearing mice receiving CCRT.
|Condition or disease||Intervention/treatment|
|Colorectal Cancer||Procedure: concurrent chemoradiation|
|Study Type :||Observational|
|Actual Enrollment :||30 participants|
|Official Title:||The Effect of Concurrent Chemoradiation on Circulating Endothelial Progenitor Cells in Colorectal Cancer|
|Study Start Date :||April 2006|
|Actual Primary Completion Date :||March 2009|
|Actual Study Completion Date :||April 2009|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00325871
|Mackay Memorial Hospital|
|Taipei, Taiwan, 104|
|Principal Investigator:||Yu-Jen Chen, MD, PhD||Department of Radiation Oncology, Mackay Memorial Hospital|