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ROSCAP: Reduction of Smoking in Cardiac Patients Study

This study has been completed.
Information provided by:
Minneapolis Veterans Affairs Medical Center Identifier:
First received: March 10, 2006
Last updated: October 23, 2008
Last verified: April 2005
Background. The ROSCAP Study was a randomized controlled trial in heart disease patients to test the effect of a smoking reduction intervention on cigarettes per day (cpd) and biochemical and clinical indicators of tobacco exposure. .

Condition Intervention
Nicotine Dependence Tobacco Dependence Cardiac Disease Behavioral: smoking reduction intervention (including NRT)

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)

Resource links provided by NLM:

Further study details as provided by Minneapolis Veterans Affairs Medical Center:

Primary Outcome Measures:
  • Smoking reduction

Secondary Outcome Measures:
  • Smoking cessation, biomarker measures

Estimated Enrollment: 180
Study Start Date: October 2000
Estimated Study Completion Date: January 2005

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • smoked at least 15 cigarettes per day and had one of 11 cardiovascular disorders: history of myocardial infarction, coronary artery bypass surgery, angioplasty, stent placement, thrombolytic therapy, angina, arrhythmia, a history of cardiac arrest, greater than 50% coronary artery stenosis by angiography, ischemia on exercise tolerance testing or congestive heart failure, required to confirm that they were unwilling or uninterested in setting a stop smoking date in the next 30 days.

Exclusion Criteria:

  • 1) unstable angina within the past 2 weeks, 2) unstable psychiatric or substance use disorders or 3) contraindications to nicotine replacement therapy (including pregnancy or intention to become pregnant)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00301626

United States, Minnesota
Minneapolis VAMC (111-0)
Minneapolis, Minnesota, United States, 55417
Sponsors and Collaborators
National Institutes of Health (NIH)
Principal Investigator: Anne Joseph, MD, MPH Minneapolis VAMC & University of Minnesota
  More Information Identifier: NCT00301626     History of Changes
Other Study ID Numbers: DA13333-02
Study First Received: March 10, 2006
Last Updated: October 23, 2008

Keywords provided by Minneapolis Veterans Affairs Medical Center:
smoking reduction

Additional relevant MeSH terms:
Tobacco Use Disorder
Heart Diseases
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Cardiovascular Diseases processed this record on September 21, 2017