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Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00300794
First Posted: March 9, 2006
Last Update Posted: November 14, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Vilnius University
  Purpose
The purpose of this study is to determine whether low-dose ketamine infusion is effective in suppressing the symptoms of opiate withdrawal during rapid opiate antagonist induction (RAI).

Condition Intervention Phase
Opiate Dependence Drug: Ketamine Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Vilnius University:

Estimated Enrollment: 60
Study Start Date: February 2003
Estimated Study Completion Date: June 2006
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Diagnosed opiate dependence according to ICD 10 and/or DSM 4;
  • Duration of substance abuse more than 1 year
  • No or minor co-morbidities;
  • Grade I-II according to physical status classification system of American Society of Anesthesiologists.

Exclusion Criteria:

  • Current history of long acting opiate or poly-substance abuse;
  • Acute medical or surgical condition;
  • Pregnancy;
  • Breastfeeding.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00300794


Locations
Lithuania
Vilnius University Emergency Hospital
Vilnius, Lithuania
Sponsors and Collaborators
Vilnius University
Investigators
Study Director: Juozas Ivaskevicius, Prof. Vilnius University Clinic of Anaesthesiology and Intensive Care
Principal Investigator: Tomas Jovaisa, MD Vilnius University Clinic of Anaesthesiology and Intensive Care
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00300794     History of Changes
Other Study ID Numbers: PROT N1 V1_5
First Submitted: March 7, 2006
First Posted: March 9, 2006
Last Update Posted: November 14, 2006
Last Verified: November 2006

Additional relevant MeSH terms:
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Ketamine
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anesthetics, Dissociative
Anesthetics, Intravenous
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action