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Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

This study has been completed.
Information provided by:
Vilnius University Identifier:
First received: March 7, 2006
Last updated: November 13, 2006
Last verified: November 2006
The purpose of this study is to determine whether low-dose ketamine infusion is effective in suppressing the symptoms of opiate withdrawal during rapid opiate antagonist induction (RAI).

Condition Intervention Phase
Opiate Dependence Drug: Ketamine Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Vilnius University:

Estimated Enrollment: 60
Study Start Date: February 2003
Estimated Study Completion Date: June 2006

Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosed opiate dependence according to ICD 10 and/or DSM 4;
  • Duration of substance abuse more than 1 year
  • No or minor co-morbidities;
  • Grade I-II according to physical status classification system of American Society of Anesthesiologists.

Exclusion Criteria:

  • Current history of long acting opiate or poly-substance abuse;
  • Acute medical or surgical condition;
  • Pregnancy;
  • Breastfeeding.
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Please refer to this study by its identifier: NCT00300794

Vilnius University Emergency Hospital
Vilnius, Lithuania
Sponsors and Collaborators
Vilnius University
Study Director: Juozas Ivaskevicius, Prof. Vilnius University Clinic of Anaesthesiology and Intensive Care
Principal Investigator: Tomas Jovaisa, MD Vilnius University Clinic of Anaesthesiology and Intensive Care
  More Information

Publications: Identifier: NCT00300794     History of Changes
Other Study ID Numbers: PROT N1 V1_5
Study First Received: March 7, 2006
Last Updated: November 13, 2006

Additional relevant MeSH terms:
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anesthetics, Dissociative
Anesthetics, Intravenous
Anesthetics, General
Central Nervous System Depressants
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action processed this record on September 21, 2017