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The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation

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ClinicalTrials.gov Identifier: NCT00284726
Recruitment Status : Completed
First Posted : February 1, 2006
Last Update Posted : December 7, 2017
Sponsor:
Information provided by:
Johns Hopkins University

Study Description
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Brief Summary:
The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.

Condition or disease Intervention/treatment Phase
Lung Transplant Recipients Device: Celsior Cold Storage Solution Phase 3

Detailed Description:
The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.
Study Design
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Study Type : Interventional  (Clinical Trial)
Official Title: A Prospective, Controlled, Randomized Study on the Effect of Cold Storage Solutions on Complement Activation and Other Mediators of Ischemic Injury in Lung Transplantation
Study Start Date : December 2000
Study Completion Date : September 2005

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Arms and Interventions
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   Child, Adult, Older Adult
Criteria

Inclusion Criteria:

Any patient undergoing a lung trasnplant at Johns Hopkins Hospital -

Exclusion Criteria:

-

Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00284726


Sponsors and Collaborators
Johns Hopkins University
Investigators
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Principal Investigator: John V. Conte, M.D. Johns Hopkins University
More Information
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ClinicalTrials.gov Identifier: NCT00284726    
Other Study ID Numbers: 00-10-25-03
First Posted: February 1, 2006    Key Record Dates
Last Update Posted: December 7, 2017
Last Verified: December 2017
Keywords provided by Johns Hopkins University:
Cytokines in lung transplantation
Cold storage solutions
Ischemic reperfusion injury
Additional relevant MeSH terms:
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Ischemia
Pathologic Processes