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Motivational Program for Smokers Enrolled in a Methadone Maintenance Program

This study has been completed.
National Cancer Institute (NCI)
Information provided by:
Butler Hospital Identifier:
First received: January 16, 2006
Last updated: March 23, 2010
Last verified: March 2010

RATIONALE: Stop-smoking programs may help patients stop smoking and prevent cancer from forming.

PURPOSE: This clinical trial is studying how well a motivational program works in helping smokers enrolled in a methadone maintenance program quit smoking.

Condition Intervention
Unspecified Adult Solid Tumor, Protocol Specific Behavioral: smoking cessation intervention Other: educational intervention

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Smoking Cessation Among Methadone Maintained Patients

Resource links provided by NLM:

Further study details as provided by Butler Hospital:

Primary Outcome Measures:
  • Nicotine Abstinence [ Time Frame: 6-months ]

Enrollment: 398
Study Start Date: June 2001
Study Completion Date: October 2004
Primary Completion Date: October 2004 (Final data collection date for primary outcome measure)
Detailed Description:


  • Determine the efficacy of a brief motivational intervention on smoking cessation in smokers enrolled in a methadone maintenance program.

OUTLINE: Patients are assigned to 1 of 2 groups.

  • Group 1: Patients undergo assessment at baseline and at 1, 3, and 6 months.
  • Group 2: Patients receive a brief motivational intervention at the time of their baseline assessment and undergo assessment as in group 1.

All patients will be offered a 2- to 3-month supply of nicotine patches.

PROJECTED ACCRUAL: A total of 400 patients will be accrued for this study.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


  • Must be currently enrolled in a methadone maintenance program
  • Smokes at least 10 cigarettes a day


  • Not pregnant
  • No concurrent medical condition that precludes the use of nicotine patches


  • No concurrent use of other nicotine replacement therapy
  Contacts and Locations
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Please refer to this study by its identifier: NCT00278226

United States, Rhode Island
Rhode Island Hospital Comprehensive Cancer Center
Providence, Rhode Island, United States, 02903
Sponsors and Collaborators
Butler Hospital
National Cancer Institute (NCI)
Study Chair: Michael Stein, MD Rhode Island Hospital
  More Information

Responsible Party: Michael Stein, MD, Butler Hospital Identifier: NCT00278226     History of Changes
Other Study ID Numbers: CDR0000452798
R01CA084392 ( U.S. NIH Grant/Contract )
Study First Received: January 16, 2006
Last Updated: March 23, 2010

Keywords provided by Butler Hospital:
unspecified adult solid tumor, protocol specific

Additional relevant MeSH terms:
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Antitussive Agents
Respiratory System Agents processed this record on August 18, 2017