The Effects of Tegaserod vs. Placebo on Whole Gut Transit Time in Patients With Chronic Constipation and Dyspepsia
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Ages Eligible for Study:
18 Years to 64 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Females aged 18 to 64 years of age
Patients must present with two or more of the following criteria for chronic constipation for at least 12 weeks prior to entering the study:
Less than 3 bowel movements per week
Hard or lumpy stools
Straining during bowel movements
Feeling of incomplete evacuation
Patients must report overlapping symptoms consistent with dyspepsia, such as mid-upper abdominal discomfort characterized by early satiety, post-meal fullness and bloating
Patients with a recent history of, or current frequency of diarrhea occuring more than once per month off of laxatives
Clinically significant diagnosis of pelvic outlet obstruction or pelvic floor dyssenergia as determined by the study physicians
Patients with constipation secondary to medication use as determined by the study physician
Patients with clinically significant abnormal TSH levels at screening
Patients that have heartburn or abdominal pain as their predominant GI symptom
Evidence of cathartic colon or a history of laxative abuse
Other protocol-defined inclusion/exclusion criteria may apply