Pharmacokinetic Study of Interaction Between Nevirapine and Methadone in HIV-1 Infected, Opioid-dependent Adults
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|ClinicalTrials.gov Identifier: NCT00273988|
Recruitment Status : Completed
First Posted : January 10, 2006
Last Update Posted : October 31, 2013
|Condition or disease||Intervention/treatment||Phase|
|Acquired Immunodeficiency Syndrome||Drug: nevirapine||Phase 4|
Ten HIV-1 infected, opioid-dependent adults on stable methadone treatment were to be enrolled in this study. This was an open-label, sequential treatment study, with methadone pharmacokinetics sampling before and after twenty-one (21) days of nevirapine administration.
All patients received the same regimen. Methadone was administered in the first treatment period, and combination treatment of methadone and nevirapine was given in the second treatment period. In the first period, patients received methadone at their current steady state dose. In the second period (study days 1-21), they also received nevirapine 200mg qd (study days 1 to 14) and 200mg bid (study days 15 to 21). Blood samples were taken at the start of the first treatment period and at the end of the second treatment period for analysis of methadone and nevirapine pharmacokinetics parameters.
It was expected that nevirapine would decrease methadone levels in this patient population.
The study compared methadone steady state exposure in the absence and presence of steady state nevirapine. A range of pharmacokinetics parameters were assessed including clearance of methadone (the primary endpoint variable), area under the concentration-time curve, maximum concentration, time to maximum concentration and minimum concentration (measured for both methadone and nevirapine).
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||10 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||A Pharmacokinetic Study to Evaluate the Interaction Between Nevirapine (Viramune®) and Methadone in HIV-1 Infected, Opioid-dependent Adults on Stable Methadone Maintenance Therapy|
|Study Start Date :||April 2002|
|Actual Primary Completion Date :||October 2003|
|Study Completion Date :||October 2003|
- Clearance of methadone at steady state in the presence and absence of nevirapine.
- Pharmacokinetics of methadone at steady state in the presence and absence of nevirapine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00273988
|Department of Genito Urinary Medicine, St James' Hospital|
|Dublin, Ireland, 8|
|Study Chair:||Boehringer Ingelheim Study Coordinator||BIL UK / Ireland|