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Benazepril for Advanced Chronic Renal Insufficiency

This study has been terminated.
Information provided by:
Southern Medical University, China Identifier:
First received: December 23, 2005
Last updated: May 4, 2006
Last verified: March 1999
The purpose of this study is to further determine whether benazepril, could safely slow the progression of renal dysfunction in non-diabetic patients with advanced renal insufficiency.

Condition Intervention
Chronic Kidney Failure Drug: Benazepril

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Southern Medical University, China:


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. serum creatinine concentration 1.5-5.0 mg/dL (133-442 µmol/L)
  2. creatinine clearance 20 to70 mL/min/1.73 m2, with variations of less than 30 percent in the three months before the screening evaluation
  3. non-diabetic renal disease
  4. persistent proteinuria (defined as urinary protein excretion greater than 0.3 g/day for three or more months without evidence of urinary-tract infection or overt heart failure [New York Heart Association class III–IV]).

Exclusion Criteria:

  • immediate need for dialysis; treatment with corticosteroids, non-steroidal anti-inflammatory drugs or immunosuppressive drugs; renovascular disease; myocardial infarction or cerebrovascular accident in the year preceding the trial; connective-tissue disease; obstructive uropathy.
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Please refer to this study by its identifier: NCT00270426

Sponsors and Collaborators
Southern Medical University, China
Principal Investigator: Fan Fan Hou, M.D.,Ph.D. Southern Medical University
  More Information

Publications: Identifier: NCT00270426     History of Changes
Other Study ID Numbers: SouthernMUC
Study First Received: December 23, 2005
Last Updated: May 4, 2006

Keywords provided by Southern Medical University, China:
Advanced Chronic Renal Insufficiency

Additional relevant MeSH terms:
Renal Insufficiency
Renal Insufficiency, Chronic
Kidney Failure, Chronic
Kidney Diseases
Urologic Diseases
Angiotensin-Converting Enzyme Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antihypertensive Agents processed this record on August 16, 2017