Evaluating Effects of a Left Bundle Branch Block

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00269659
Recruitment Status : Completed
First Posted : December 23, 2005
Last Update Posted : February 24, 2009
The Interuniversity Cardiology Institute of the Netherlands
Information provided by:
VU University Medical Center

Brief Summary:

A left bundle branch block (LBBB) is related to abnormal cardiac conduction and mechanical asynchrony and is associated with hypertension and coronary artery disease. Improved evaluation of left ventricular (LV) mechanical asynchrony is needed, because of the increasing number of patients with a LBBB and heart failure. A variety of patterns of mechanical activation can be observed in LBBB patients.

Novel imaging modalities such as tissue Doppler imaging, real-time 3D echocardiography and cardiovascular magnetic resonance imaging provide information about regional and global LV function in healthy subjects, patients without a LBBB with heart failure, patients with a LBBB without heart failure, and patients with a LBBB with heart failure.

The investigators want to evaluate the different patient groups with the novel imaging modalities and they want to compare the novel imaging modalities with each other.

The investigators hypothesized that, between the groups, differences concerning regional and global LV function are measurable.

Each novel imaging technique has its own advantages and limitations but are comparable in measuring regional and global LV function.

Condition or disease
Mechanical Dyssynchrony Heart Failure Bundle-Branch Block

Detailed Description:

Within a time period of 3 years we evaluate different groups of patients and measure regional and global cardiac function.

Therefore, we developed an echocardiography screening-protocol in which we use conventional 2D echocardiography and conventional Doppler echocardiography, extended with tissue Doppler imaging and real-time 3D echo acquisitions.

In a limited group of patients we perform a specially designed cardiovascular magnetic resonance imaging protocol which uses artificially induced grid-lines to evaluate regional and global cardiac function.

Patients are referred to our hospital because of evaluation of their LBBB and or heart failure. We ask them if they would like to undergo the echocardiography and the cardiovascular magnetic resonance imaging.

After a year we want to repeat the measurements in a small group of the patients to re-evaluate regional and global cardiac function.

All patients should have a sinus rhythm and adequate acoustic windows. Patients should not have contraindications for cardiovascular magnetic resonance imaging.

Study Type : Observational
Estimated Enrollment : 100 participants
Time Perspective: Prospective
Official Title: Serial Evaluation of Left Bundle Branch Block; Role of New Imaging Techniques. Three-Dimensional Echocardiography, Tissue Doppler Imaging, and Magnetic Resonance Imaging
Study Start Date : January 2004
Actual Primary Completion Date : July 2007
Actual Study Completion Date : July 2007

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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Aged 18-85 years
  • Left bundle branch block with or without heart failure
  • Narrow QRS duration with or without heart failure

Exclusion Criteria:

  • No informed consent
  • No sinus rhythm
  • Poor acoustic window
  • For cardiovascular magnetic resonance imaging part:

    • claustrophobia
    • devices

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00269659

VU Medical Center
Amsterdam, Netherlands, 1081 HV
Sponsors and Collaborators
VU University Medical Center
The Interuniversity Cardiology Institute of the Netherlands
Study Chair: Otto Kamp, MD, PhD VU University Medical Center Identifier: NCT00269659     History of Changes
Other Study ID Numbers: VUMC 2003/147
First Posted: December 23, 2005    Key Record Dates
Last Update Posted: February 24, 2009
Last Verified: February 2009

Keywords provided by VU University Medical Center:
Left Bundle Branch Block
Regional cardiac function
Global cardiac function
Mechanical asynchrony
2D echocardiography
Tissue Doppler Imaging
Real-time 3D echocardiography
Cardiovascular Magnetic Resonance Imaging-tagging

Additional relevant MeSH terms:
Heart Failure
Bundle-Branch Block
Heart Block
Heart Diseases
Cardiovascular Diseases
Arrhythmias, Cardiac
Pathologic Processes