An Open-Label Study Of Lamictal In Neurotic Excoriation
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00269594 |
Recruitment Status :
Completed
First Posted : December 23, 2005
Last Update Posted : April 30, 2007
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Neurotic Disorders Obsessive-Compulsive Disorder | Drug: Lamictal (lamotrigine) | Phase 2 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 25 participants |
Allocation: | Non-Randomized |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | An Open-Label Study of Lamictal In Neurotic Excoriation |
Study Start Date : | January 2006 |
Actual Study Completion Date : | September 2006 |

- Yale-Brown Obsessive Compulsive Scale Modified for Neurotic Excoriation
- Skin Picking Symptom Assessment Scale (SP-SAS) and the Clinical Global Impression scale

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- men and women age 18-65
- current diagnosis of neurotic excoriation
Exclusion Criteria:
- unstable medical illness or clinically significant abnormalities on prestudy laboratory tests or physical examination
- history of seizures
- myocardial infarction within 6 months
- current pregnancy or lactation, or inadequate contraception in women of childbearing potential
- a need for medication other than Lamictal with possible psychotropic effects or unfavorable interactions with Lamictal
- clinically significant suicidality
- lifetime history of DSM-IV bipolar disorder type I, dementia, or schizophrenia or any other DSM-IV psychotic disorder
- current or recent (past 3 months) DSM-IV substance abuse or dependence
- illegal substance use within 2 weeks of study initiation
- initiation of psychotherapy or behavior therapy from a mental health professional within 3 months prior to study baseline
- previous treatment with Lamictal
- treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline
- current treatment with an anti-epileptic medication and
- patients who have previously been diagnosed with a medical condition that cause skin itchiness (e.g. liver, kidney, and blood diseases, etopic allergies)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00269594
United States, Minnesota | |
University of Minnesota | |
Minneapolis, Minnesota, United States, 55454 |
Principal Investigator: | Jon E Grant, JD, MD | University of Minnesota |
ClinicalTrials.gov Identifier: | NCT00269594 |
Other Study ID Numbers: |
0510M77009 |
First Posted: | December 23, 2005 Key Record Dates |
Last Update Posted: | April 30, 2007 |
Last Verified: | April 2007 |
Skin Picking Pick Neurotic Excoriation |
Disease Compulsive Personality Disorder Obsessive-Compulsive Disorder Neurotic Disorders Pathologic Processes Personality Disorders Mental Disorders Anxiety Disorders Lamotrigine Anticonvulsants |
Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Physiological Effects of Drugs Antipsychotic Agents Tranquilizing Agents Central Nervous System Depressants Psychotropic Drugs Sodium Channel Blockers |