Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1
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ClinicalTrials.gov Identifier: NCT00249496 |
Recruitment Status
:
Completed
First Posted
: November 7, 2005
Results First Posted
: December 16, 2016
Last Update Posted
: September 18, 2017
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Alcohol Use Drug Use Risk Behavior Sexual Behavior | Behavioral: Contingency management Behavioral: Employment Only | Not Applicable |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 51 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Therapeutic Workplace Maintenance Study |
Study Start Date : | October 2003 |
Actual Primary Completion Date : | August 2007 |
Actual Study Completion Date : | August 2007 |

Arm | Intervention/treatment |
---|---|
Active Comparator: Employment Only
Employment Only participants will be offered employment for one year, but these participants will not have to provide drug-free urine samples to work.
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Behavioral: Employment Only
Employment Only participants will be offered employment for one year, but these participants will not have to provide drug-free urine samples to work.
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Experimental: Contingency Management
Participants in the Contingency Management group will be employed for one year in a Therapeutic Workplace business and will have to provide drug-free urine samples to work and earn salary.
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Behavioral: Contingency management
Participants in the Contingency Management group will be employed for one year in a Therapeutic Workplace business and will have to provide drug-free urine samples to work and earn salary.
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- Percentage of Monthly Urine Samples That Are Negative for Cocaine [ Time Frame: 1 year ]The percentage of urine samples collected at monthly assessments that are negative for cocaine.
- Percentage of Monday, Wednesday and Friday Urine Samples That Are Negative for Cocaine [ Time Frame: 1 year ]
(The number of Monday, Wednesday and Friday urine samples negative for cocaine/total number of urine samples) x 100.
We have not confirmed the accuracy/completeness of the Mon, Wed, Fri urine data at this point. In addition, the monthly data had less missing data than the Monday, Wednesday and Friday data and were sufficient to show the main results of the trial.
- Percentage of 30-day Assessment Urine Samples Negative for Opiates [ Time Frame: 1 year ](The number of monthly urine samples negative for opiates/total number of urine samples) x 100
- Percentage of Monday, Wednesday and Friday Urine Samples That Are Negative for Opiates [ Time Frame: 1 year ]
(The number of Monday, Wednesday and Friday urine samples negative for opiates/total number of urine samples) x 100.
We have not confirmed the accuracy/completeness of the Mon, Wed, Fri urine data at this point. In addition, the monthly data had less missing data than the Monday, Wednesday and Friday data and were sufficient to show the main results of the trial.
- HIV Risk Behaviors [ Time Frame: 1 year ]Percentage of people reporting that they traded sex for drugs or money

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Applicants in methadone treatment may be eligible to participate in Phase 1 of the study.
- Applicants will be blind to the full details of the eligibility criteria.
- Unemployed
- Provided a urine sample at intake with a detectable concentration of cocaine metabolite or provided a cocaine positive sample during regular urinalysis testing at a methadone maintenance program
- Met DSM-IV criteria for cocaine dependence
- Were receiving welfare benefits in Baltimore, MD
- Received a score of less than or equal to 80% correct on a reading assessment
Exclusion Criteria
- Being at imminent risk for suicide
- Reported hallucinations
- Being incarcerated or otherwise under constant monitoring
- Earned less than or equal to $200 in unreported taxable income from legal activity in the previous month
- Having physical limitations that prevented typing

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00249496
United States, Maryland | |
The Center for Learning and Health | |
Baltimore, Maryland, United States, 21224 |
Principal Investigator: | Kenneth Silverman, Ph.D. | Johns Hopkins University |
Publications of Results:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Johns Hopkins University |
ClinicalTrials.gov Identifier: | NCT00249496 History of Changes |
Other Study ID Numbers: |
WIRB 2093 R01DA013107 ( U.S. NIH Grant/Contract ) |
First Posted: | November 7, 2005 Key Record Dates |
Results First Posted: | December 16, 2016 |
Last Update Posted: | September 18, 2017 |
Last Verified: | August 2017 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Plan Description: | The results were published in a peer-reviewed journal. |
Keywords provided by Johns Hopkins University:
cocaine opioids contingency management sexual risk HIV |