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Magnetic Resonance Imaging (MRI) of Brain Iron in Neurodegenerative Disease

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ClinicalTrials.gov Identifier: NCT00249080
Recruitment Status : Completed
First Posted : November 7, 2005
Last Update Posted : August 24, 2009
Sponsor:
Collaborator:
Information provided by:

Study Description
Brief Summary:
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis are recognized as a major health concern at the present time. There is information in magnetic resonance imaging (MRI) studies regarding the role of brain iron in normal brain aging that may be enhanced with the use of better scanning equipment and procedures, and by correlating this information with clinical data. This research study aims to develop and evaluate a number of techniques that can potentially improve the effectiveness of three tesla (3T) magnetic resonance imaging of neurodegenerative brain disorders.

Condition or disease
Neurodegenerative Diseases Mild Cognitive Impairment

Detailed Description:

Eligibility: A healthy person without memory complaints or someone with neurodegenerative disease. However, the person should not have metal in the body (ie, pacemaker, implants, shrapnel, etc.), should not be pregnant, and should not have claustrophobic anxieties.

Study Procedures: During a regular office visit, a neurologist will perform a routine physical and neurological examination, including your medical and family history, to determine your eligibility for this study. You will then be scheduled for a series of neuropsychological tests, which take between 1 to 1.5 hours, and an MRI scan, which takes approximately 1 hour to complete. This is a longitudinal study and you may be asked to repeat these procedures approximately every six months for the duration of this 2 year project.


Study Design

Study Type : Observational
Actual Enrollment : 182 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: High Field MRI of Brain Iron in Neurodegenerative Disease
Study Start Date : June 2005
Study Completion Date : August 2007


Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Approximately equal numbers of subjects with clinically diagnosed Alzheimer's disease, multiple sclerosis, Parkinson's disease and normal controls (age and gender matched).
Criteria

Inclusion Criteria:

  • 18 years or older
  • Healthy person without memory complaints OR person diagnosed with a neurodegenerative disease (ie, Alzheimer's disease, Parkinson's disease, multiple sclerosis)

Exclusion Criteria:

  • MR contraindication such as metal in body (ie, pacemaker, implant, shrapnel, etc.)
  • Pregnant
  • Claustrophobic anxieties
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00249080


Sponsors and Collaborators
Albany Medical College
United States Department of Defense
Investigators
Study Director: Earl A Zimmerman, MD Albany Medical College
Principal Investigator: John F Schenck, MD, PhD GE Global Research Center & Neurosciences Advanced Imaging Research Center
More Information

Additional Information:
Publications:
Responsible Party: John Schenck, MD PhD; Principal Investigator, Albany Medical College
ClinicalTrials.gov Identifier: NCT00249080     History of Changes
Other Study ID Numbers: AMC-IRB-1599
A-13214
First Posted: November 7, 2005    Key Record Dates
Last Update Posted: August 24, 2009
Last Verified: August 2009

Keywords provided by Albany Medical College:
3T MRI
neurodegenerative disease
Alzheimer's disease
spectroscopy
Normal, healthy subject without memory complaint
Not pregnant
MR compatible

Additional relevant MeSH terms:
Cognitive Dysfunction
Neurodegenerative Diseases
Cognition Disorders
Neurocognitive Disorders
Mental Disorders
Nervous System Diseases