Vitamin D Deficiency: Bone Loss and Vascular Dysfunction
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To learn if there is a connection between low vitamin D level and hardening of the arteries.
Condition or disease
Procedure: 10 vit. D deficient subjects take vit. D for 3 months.
Osteoporosis and vascular disease are two of the most common disorders affecting postmenopausal women. A potential association, beyond aging, has long been speculated. Our previous study revealed evidence of loss of vascular compliance in postmenopausal women with lower bone density, suggesting women with lower bone density had "stiffer" blood vessels. This proposal further investigates that association and a potential role of vitamin D deficiency as a possible common link between both bone loss and "hardening of the arteries".
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Ages Eligible for Study:
50 Years to 90 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Females ages 50-70 with ability to give informed consent
One year past last menstrual period
20 women with Vitamin D levels < 15 mg/ml
20 women with Vitamin D levels > 30 mg/ml
women receiving hormone replacement therapy
women receiving medication known to effect vascular compliance, including anti-hypertension medications
subjects receiving therapy for osteoporosis
history of metabolic bone disease
current or previous use of medications known to accelerate bone loss