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Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario

This study has been completed.
Information provided by:
McMaster University Identifier:
First received: October 6, 2005
Last updated: March 16, 2009
Last verified: March 2009
Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious irritable bowel syndrome (PI-IBS) remains poorly understood. This could allow material in the bowel to reach deeper tissues of the bowel wall leading to inflammation and changes in muscle and nerve function. This is also early evidence that genetic programming of people with PI-IBS prevents them from turning off inflammation once it begins. Literature suggests that IBS may develop at greater rates in individuals with pro-inflammatory genotype and that these individuals may be at increased risk of inflammatory bowel diseases (IBD).

Irritable Bowel Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario

Resource links provided by NLM:

Further study details as provided by McMaster University:

Primary Outcome Measures:
  • Number of Participants With Post Infectious Irritable Bowel Syndrome [ Time Frame: 8 years ]

Enrollment: 4561
Study Start Date: January 2002
Study Completion Date: August 2008
Primary Completion Date: August 2008 (Final data collection date for primary outcome measure)
Unexposed to gastroenteritis
Exposed to gastroenteritis

Detailed Description:
This research will study chronic gastrointestinal problems in the residents of Walkerton, Ontario region. Determine whether acute bacterial infection is a risk factor for development of inflammatory bowel disease using the population of Walkerton as a cohort. We hypothesize that exposure to bacterial infection leads to development of post infectious irritable bowel syndrome which is associated with an increase in intestinal permeability and immune activation with low grade intestinal inflammation and that this sequence of events will trigger inflammatory bowel disease in genetically susceptible individuals

Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
residents of walkerton

Inclusion Criteria:

  • Participants must be residents of the Walkerton, Ontario region at the time of Outbreak who consented to the study

Exclusion Criteria:

  • Non residents of Walkerton Ontario at the time of outbreak
  Contacts and Locations
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Please refer to this study by its identifier: NCT00235326

Canada, Ontario
Walkerton, Ontario, Canada, N0G 2V0
Sponsors and Collaborators
McMaster University
Principal Investigator: John k Marshall, MD, MSc McMaster University
  More Information

Responsible Party: John Marshall, Mcmaster University Identifier: NCT00235326     History of Changes
Other Study ID Numbers: 02-026; 05-346
Study First Received: October 6, 2005
Results First Received: February 5, 2009
Last Updated: March 16, 2009

Keywords provided by McMaster University:
residents of Walkerton ontario at outbreak

Additional relevant MeSH terms:
Irritable Bowel Syndrome
Colonic Diseases, Functional
Colonic Diseases
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases processed this record on September 21, 2017