Assessing CPR Quality During In-Hospital Cardiac Arrest
|Cardiac Arrest||Device: investigational monitor/defibrillator with CPR feedback||Phase 2 Phase 3|
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Assessment of Cardiopulmonary Resuscitation Quality During In-Hospital Cardiac Arrest|
- parameters of CPR quality:
- chest compression rate
- chest compression depth
- ventilation rate
- ventilation depth
- CPR pause times
- return of spontaneous circulation (ROSC)
- survival to hospital discharge
|Study Start Date:||December 2002|
|Estimated Study Completion Date:||September 2005|
Patients who suffer cardiac arrest during their hospitalization at the University of Chicago hospitals are given CPR and other resuscitation measures by trained physician and nurse teams. This care is given with the use of defibrillators to monitor cardiac rhythm as well as provide defibrillation as needed.
We have worked closely with engineers at Laerdal Medical Corporation to develop a defibrillator that passively monitors the quality of CPR via additional external sensors (see details in the following reference: Abella BS, Alvarado JP, Myklebust H, Edelson DP, Barry A, O'Hearn N, Vanden Hoek TL, Becker LB. Quality of cardiopulmonary resuscitation during in-hospital cardiac arrest. JAMA. 2005;293:305-10).
Patients who suffer in-hospital arrest are enrolled (provided they are over 16 years of age, are not pregnant, and are not in the operating room or emergency room setting) with mechanisms to satisfy IRB waiver of consent provisions. These patients receive the same care as before the study, but CPR parameters are recorded by the device. In addition, the device provides audio/visual "coaching" in CPR, based on the actual performance of CPR as measured.
We hypothesize that this coaching will improve CPR quality and hopefully improve survival from cardiac arrest.
The first phase of investigation is now complete, where patients were enrolled and studied without feedback ("baseline" group). Now we are enrolling patients into a second group with feedback provided. Enrollment is nearly complete for this second group. We will then evaluate the baseline and feedback groups to ascertain whether CPR improved over the two cohorts.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00228293
|United States, Illinois|
|University of Chicago Hospitals|
|Chicago, Illinois, United States, 60637|
|Principal Investigator:||Lance B Becker, MD||Professor of Medicine, University of Chicago|