Mitochondrial Impairment in Muscle Insulin Resistance
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|ClinicalTrials.gov Identifier: NCT00222924|
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : December 19, 2007
|Condition or disease||Intervention/treatment||Phase|
|Diabetes Obesity||Behavioral: weight loss/ exercise||Not Applicable|
Recent research from our laboratory has detected novel findings concerning damage to mitochondria within skeletal muscle in type 2 diabetes (type 2 DM), damage that is evident morphologically and by functional criteria. In this project, we propose, firstly, to more fully test this hypothesis of an impaired bio-energetic capacity, and to begin to examine the pathogenesis of damage to mitochondria in type 2 DM. We are also interested in assessing the potential for reversing damage, and improving functional capacity of mitochondria through a weight loss or a combined exercise and weight loss intervention.
The first specific aim is to measure the functional capacity of mitochondria in human skeletal muscle in type 2 DM and in those at apparent risk for type 2 DM (obese, sedentary, non-diabetic adults with the Metabolic Syndrome and/or impaired glucose tolerance). The second specific aim is to examine the morphology of mitochondria in human skeletal muscle in type 2 DM and in those at apparent risk for type 2 DM. The third specific aim is to examine the pathogenesis of mitochondrial damage in type 2 DM and in those at apparent risk for type 2 DM. The fourth specific aim is to assess whether exercise and diet can improve mitochondrial function and morphology in type 2 DM and in those at apparent risk for type 2 DM.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||49 participants|
|Intervention Model:||Factorial Assignment|
|Masking:||None (Open Label)|
|Official Title:||Mitochondrial Impairment in Muscle Insulin Resistance|
|Study Start Date :||December 2003|
|Actual Study Completion Date :||December 2006|
- To measure the functional capacity of mitochondria in skeletal muscle of those with T2DM and those at increased risk of developing T2DM
- To assess whether exercise and diet can improve mitochondrial function and morphology.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00222924
|United States, Pennsylvania|
|University of Pittsburgh|
|Pittsburgh, Pennsylvania, United States, 15213|
|Principal Investigator:||David E. Kelley, MD||University of Pittsburgh|