Role of Left Ventricular Pacing Site
Recruitment status was: Recruiting
Device: left ventricular pacing
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind
Primary Purpose: Treatment
|Official Title:||Importance of Left Ventricular Pacing Site in Biventricular Resynchronization Therapy for Severe Heart Failure|
- Variation in left ventricular dp/dt max
- pressures and volumes of the left ventricle
- stroke work
- surface ECG repolarisation
|Study Start Date:||November 2003|
|Estimated Study Completion Date:||December 2007|
Background. Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site.
Design. Single-blind, monocentric, randomized cross-over study comparing 11 left ventricular pacing sites in a random order.
Intervention. Left ventricular DDD pacing on 11 ventricular sites, prior to the implantation. At each pacing site, a control hemodynamics will be obtained in AAI pacing at the same pacing rate. At each pacing site, 2 AV delays, a short and a long one, will be assessed.
Eligibility criteria. Patients referred for cardiac resynchronization therapy for heart failure
Outcomes. Hemodynamic measures using pressure-volume catheters.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00221780
|Hôpital Cardiologique du Haut Lévêque, Rythmology department, Pr CLEMENTY, 3rd Floor|
|Pessac, France, 33604|
|Principal Investigator:||Pierre Jaïs, Dr||University Hospital, Bordeaux|
|Study Chair:||Paul Perez, Dr||University Hospital, Bordeaux|