Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00221052
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : October 11, 2006
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Brief Summary:

Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease. The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease development.

The purpose of this study is to determine the role of inflammation on glucose metabolism and insulin resistance. In this study the effect of the anti-inflammatory treatment diclofenac on markers of inflammation and on parameters of glucose metabolism will be studied.

Condition or disease Intervention/treatment Phase
Overweight Obesity Inflammation Drug: Diclofenac Not Applicable

Study Type : Interventional  (Clinical Trial)
Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Official Title: Relation Between Reduction of the Inflammatory Status and Glucose Metabolism in Healthy Overweight Men
Study Start Date : June 2005
Study Completion Date : July 2005

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U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Body Mass Index (BMI): 25.1 – 32.0 kg/m2
  • Normal Dutch eating habits

Exclusion Criteria:

  • diabetes, cardiovascular disease or hypertension
  • Not suitable to receive diclofenac treatment
  • Smoking
  • Extreme physical activity (more than 6 hours/week)
  • Reported slimming or medically prescribed diet

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00221052

TNO Quality of Life
Zeist, Netherlands, 3700 AJ
Sponsors and Collaborators
Principal Investigator: Trinette van Vliet, PhD TNO Quality of Life, Location Zeist

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00221052     History of Changes
Other Study ID Numbers: TNO-P6374
First Posted: September 22, 2005    Key Record Dates
Last Update Posted: October 11, 2006
Last Verified: October 2006

Additional relevant MeSH terms:
Pathologic Processes
Body Weight
Signs and Symptoms
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action