Disease Modifying Genes in Severe Asthma

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
New York University School of Medicine
ClinicalTrials.gov Identifier:
First received: September 19, 2005
Last updated: January 9, 2015
Last verified: January 2015
Gene and protein bank to study disease modifying and susceptibility genes and proteins in urban patients with asthma.


Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Disease Modifying Genes in Severe Asthma

Resource links provided by NLM:

Further study details as provided by New York University School of Medicine:

Primary Outcome Measures:
  • To recruit and characterize a cohort of subjects with asthma who reside in a high pollution, high asthma risk neighborhood [ Time Frame: five yeARS ] [ Designated as safety issue: Yes ]

Biospecimen Retention:   Samples With DNA
The total amount of blood drawn is approximately 5 tablespoons (75 ml). The blood sample will be processed to isolate "genetic material" (mainly DNA, RNA and protein). This genetic material will be used to try to identify the "genetic factors" or genes that a person inherits that make him or her more likely to develop asthma. The blood is used to test for allergies to weeds, trees, insects and molds (RAST) and a complete blood count.

Estimated Enrollment: 2000
Study Start Date: April 2002
Estimated Primary Completion Date: January 2016 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
All individuals approached for participation in the Research Registry shall be able to read or comprehend English. Since participation in the Research Registry does not involve a risk of physical harm, women of childbearing potential will not be queried as to pregnancy status or tested for pregnancy unless they are requested to undergo a methacholine challenge test. There are no additional inclusion/exclusion criteria.

Inclusion Criteria:

  • Ages 18 and above

Exclusion Criteria:

  • Greater than 10 pack year tobacco history
  • Lung diseases other than asthma
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00212537

United States, New York
NYU School of Medicine
New York, New York, United States, 10016
Sponsors and Collaborators
New York University School of Medicine
Principal Investigator: Joan Reibman, MD NYU School of Medicine
  More Information

No publications provided by New York University School of Medicine

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: New York University School of Medicine
ClinicalTrials.gov Identifier: NCT00212537     History of Changes
Other Study ID Numbers: H9698 
Study First Received: September 19, 2005
Last Updated: January 9, 2015
Health Authority: United States: Institutional Review Board

Keywords provided by New York University School of Medicine:
Asthma and normal

Additional relevant MeSH terms:
Bronchial Diseases
Hypersensitivity, Immediate
Immune System Diseases
Lung Diseases
Lung Diseases, Obstructive
Respiratory Hypersensitivity
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on February 11, 2016