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The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2005 by Uniwersytet Mikolaja Kopernika w Toruniu.
Recruitment status was:  Active, not recruiting
Information provided by:
Uniwersytet Mikolaja Kopernika w Toruniu Identifier:
First received: September 13, 2005
Last updated: November 30, 2005
Last verified: August 2005
Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks.

Condition Intervention
Kidney Transplantation
Behavioral: Oxidative stress in kidney transplant recipients

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

Resource links provided by NLM:

Further study details as provided by Uniwersytet Mikolaja Kopernika w Toruniu:

Estimated Enrollment: 60
Study Start Date: April 2003
Estimated Study Completion Date: September 2005
Detailed Description:

Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan.

Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion).

Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • consecutive patients accepted for and undergoing cadaveric kidney transplantation

Exclusion Criteria:

  • no informed consent
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Please refer to this study by its identifier: NCT00204178

Klinika Transplantologii, Szpital Uniwersytecki, ul. M. Sklodowskiej-Curie 9
Bydgoszcz, Poland, 85-094
Sponsors and Collaborators
Uniwersytet Mikolaja Kopernika w Toruniu
Study Director: Zbigniew Wlodarczyk, MD,PhD Klinika Transplantologii Collegium Medicum UMK w Toruniu
  More Information Identifier: NCT00204178     History of Changes
Other Study ID Numbers: KB/38/2003
Study First Received: September 13, 2005
Last Updated: November 30, 2005

Keywords provided by Uniwersytet Mikolaja Kopernika w Toruniu:
Kidney transplantation
Reperfusion injury

Additional relevant MeSH terms:
Reperfusion Injury
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications processed this record on May 25, 2017