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The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

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ClinicalTrials.gov Identifier: NCT00204178
Recruitment Status : Unknown
Verified August 2005 by Uniwersytet Mikolaja Kopernika w Toruniu.
Recruitment status was:  Active, not recruiting
First Posted : September 20, 2005
Last Update Posted : December 1, 2005
Sponsor:
Information provided by:
Uniwersytet Mikolaja Kopernika w Toruniu

Brief Summary:
Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks.

Condition or disease Intervention/treatment
Kidney Transplantation Behavioral: Oxidative stress in kidney transplant recipients

Detailed Description:

Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan.

Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion).

Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.


Study Type : Observational
Enrollment : 60 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney
Study Start Date : April 2003
Study Completion Date : September 2005

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • consecutive patients accepted for and undergoing cadaveric kidney transplantation

Exclusion Criteria:

  • no informed consent

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00204178


Locations
Poland
Klinika Transplantologii, Szpital Uniwersytecki, ul. M. Sklodowskiej-Curie 9
Bydgoszcz, Poland, 85-094
Sponsors and Collaborators
Uniwersytet Mikolaja Kopernika w Toruniu
Investigators
Study Director: Zbigniew Wlodarczyk, MD,PhD Klinika Transplantologii Collegium Medicum UMK w Toruniu

ClinicalTrials.gov Identifier: NCT00204178     History of Changes
Other Study ID Numbers: KB/38/2003
First Posted: September 20, 2005    Key Record Dates
Last Update Posted: December 1, 2005
Last Verified: August 2005

Keywords provided by Uniwersytet Mikolaja Kopernika w Toruniu:
Kidney transplantation
Reperfusion injury

Additional relevant MeSH terms:
Ischemia
Reperfusion Injury
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications