German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
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ClinicalTrials.gov Identifier: NCT00198978
Recruitment Status : Unknown
Verified June 2008 by Johann Wolfgang Goethe University Hospital. Recruitment status was: Recruiting
The study evaluates the efficacy and tolerability of a dose-reduced chemotherapy for the treatment of elderly patients with acute lymphoblastic leukemia. In patients with expression of CD20 on leukemic cells the efficacy and tolerability of additional application of Rituximab together with chemotherapy is evaluated.
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Ages Eligible for Study:
55 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Diagnosis of acute lymphoblastic leukemia (pro B, pre B, c-ALL or T-ALL), proved by morphology and immunophenotyping
Age > 55 yrs (no upper age limit)
Written informed consent
Severe leukemia associated complications, not controllable before therapy onset e.g.
life threatening infections as sepsis, pneumonia, hypoxia, shock, life threatening bleeding)
Severe comorbidity e.g.
decompensated renal failure if not caused by leukemia with Creatinine > 2x ULN