Second Line Therapy for the Cure of Helicobacter Pylori (H. Pylori) Infection
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|ClinicalTrials.gov Identifier: NCT00197418|
Recruitment Status : Unknown
Verified March 2003 by Hamamatsu University.
Recruitment status was: Recruiting
First Posted : September 20, 2005
Last Update Posted : March 21, 2006
Proton pump inhibitors (PPIs) are mainly metabolized in the liver by CYP2C19, one of the cytochrome P450 isoenzymes, which shows a genetic polymorphism associated with enzyme activities. The most essential role of a PPI in H. pylori eradication therapy is to make antibiotics more stable and bioavailable in the stomach by raising intragastric pH to neutral levels.
Most patients who have failed in the eradication of H. pylori infection by triple therapy with a PPI, amoxicillin (AMPC) and clarithromycin (CAM) at standard doses have extensive metabolizer (EM) genotypes of CYP2C19 and/or are infected with CAM-resistant strains of H. pylori.
Four-times daily dosing of a PPI could achieve complete gastric acid inhibition. Dual therapy with 4-times daily dosing of a PPI and AMPC could yield sufficient re-eradication rates in patients with EM genotype of CYP2C19.
Metronidazole (MNZ)-based re-eradication therapy, such as triple PPI/AMPC/MNZ therapy, also achieved high eradication rates and has been recommended as the second line therapy in Japan. But carcinogenic actions of MNZ have been unclear.
The purpose of this study is to compare the re-eradication rates of H. pylori infection by the dual high-dose PPI/AMPC therapy and triple PPI/AMPC/MNZ therapy, and to validate the efficacies of these re-eradication regimens as second line eradication therapies.
|Condition or disease||Intervention/treatment||Phase|
|Helicobacter Infections Gastritis Gastric Ulcer Duodenal Ulcer||Drug: rabeprazole, amoxicillin, clarithromycin, metronidazole||Phase 2 Phase 3|
|Study Type :||Interventional (Clinical Trial)|
|Intervention Model:||Factorial Assignment|
|Masking:||None (Open Label)|
|Official Title:||Dual Therapy With High-Dose of Rabeprazole and Amoxicilline Versus Triple Therapy With Rabeprazole, Amoxicilline and Metronidazole as the Second Line Therapy for the Cure of H. Pylori Infection|
|Study Start Date :||August 2003|
- Which treatment yields the higher re-eradication rate of H. pylori infection
- Side effects
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00197418
|Contact: Naohito Shirai, MD., PhDfirstname.lastname@example.org|
|Hamamatsu University School of Medicine||Recruiting|
|Hamamatsu, Shizuoka, Japan, 431-3192|
|Contact: Naohito Shirai, MD., PhD 81-534-2788 email@example.com|
|Principal Investigator: Takahisa Furuta, MD., PhD|
|Study Chair:||Naohito Shirai, MD., PhD||Hamamatsu University|