The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids
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|ClinicalTrials.gov Identifier: NCT00184899|
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : March 1, 2007
The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association. The investigators hypothesize that in patients with obesity and the metabolic syndrome, an increased intracellular concentration of long-chain fatty acyl (LCFA)-CoA (the intracellular equivalent of free fatty acids) induces an increase in adenosine. Adenosine receptor stimulation, in turn, induces vasodilation and sympathetic activation.
The investigators aimed to assess this effect of free fatty acids on the adenosine system in healthy volunteers.
|Condition or disease||Intervention/treatment||Phase|
|Obesity Metabolic Syndrome X||Drug: Intravenous infusion of Intralipid/heparin Drug: Intravenous infusion of Glycerol/heparin||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids|
|Study Start Date :||August 2005|
|Study Completion Date :||August 2006|
- Forearm blood flow
- Vasoactive effect of caffeine
- Sympathetic activity (noradrenaline spillover, spectral analysis)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00184899
|Radboud University Nijmegen Medical Centre|
|Nijmegen, Netherlands, 6500HB|
|Principal Investigator:||Paul Smits, MD, PhD||Radboud University|