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Family Cognitive Behavioral Therapy for Preventing Depression in Children

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2017 by Vanderbilt University
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Bruce Compas, Vanderbilt University Identifier:
First received: September 13, 2005
Last updated: April 11, 2017
Last verified: April 2017
This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus educational treatment in preventing depression in the children of parents with a history of depression.

Condition Intervention
Behavioral: Family Cognitive Behavioral Therapy (CBT)
Behavioral: Depression Education

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description:
Repeated measures ANOCA design.
Masking: Investigator, Outcomes Assessor
Masking Description:
Investigators and outcome assessors are masked to condition of particpants.
Primary Purpose: Prevention
Official Title: Family Cognitive Behavioral Prevention of Depression in Children of Parents With a History of Major Depressive Disorder

Further study details as provided by Vanderbilt University:

Primary Outcome Measures:
  • Depression, anxiety, and disruptive behavior problems in children; measured at baseline and Week 12 [ Time Frame: 2 years ]
  • Depression in parents; measured at baseline and Week 12 [ Time Frame: 2 years ]

Secondary Outcome Measures:
  • Parenting skills of parents; measured at baseline and Week 12 [ Time Frame: 2 years ]
  • Coping skills of children; measured at baseline and Week 12 [ Time Frame: 2 years ]
  • Quality of parent-child relationship; measured at baseline and Week 12 [ Time Frame: 2 years ]

Estimated Enrollment: 750
Actual Study Start Date: August 1, 2010
Estimated Study Completion Date: December 31, 2017
Primary Completion Date: December 31, 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Family Group Cognitive Behavioral
Family group cognitive behavioral program for families of parents with a history of depression to teach parenting skills to parents and coping skills to children.
Behavioral: Family Cognitive Behavioral Therapy (CBT)
Active Comparator: Written Information Control
Provision of information about depression to parents with a history of depression and their children.
Behavioral: Depression Education

Detailed Description:

Depression is a serious condition that can affect a person's work, relationships, and quality of life. Studies have shown that children of depressed parents are at a higher risk for developing depression than those whose parents have not experienced depression. Safe and effective treatments that can help prevent children of depressed parents from becoming depressed are needed. This study will compare CBT to depression education to determine which is more effective in preventing depression in the children of depressed parents.

Families will be randomly assigned to receive weekly sessions of either CBT or depression education for 12 weeks. Parents in the CBT group will be taught skills to more effectively raise their children and to better manage their depressive symptoms; their children will be taught skills to cope with the stress of their parents' depression. Families in the education group will be informed about the ways that depression can affect individuals with depression and their families.

Study visits will occur at study entry and at Week 12. Several follow-up visits will occur for up to 2 years after the interventional part of the study. At each visit, a clinician will make direct observations of the depressed parent's interaction with his or her children. In addition, families will be interviewed and will complete questionnaires about the parent's depressive symptoms and family interaction.


Ages Eligible for Study:   10 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria for Participating Families:

  • Families with at least one parent with a history of depression during the life of his or her child
  • Families with at least one child between the age of 10 and 15
  • Parent or guardian willing to provide informed consent for participating children

Exclusion Criteria for All Participants:

  • Parent with bipolar disorder or schizophrenia
  • Child with conduct disorder or pervasive developmental disorder
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00183482

Contact: Bruce E. Compas, PhD 615-322-8306

United States, Tennessee
Vanderbilt University Recruiting
Nashville, Tennessee, United States, 37203
Contact: Bruce E. Compas, PhD    615-322-8306   
Principal Investigator: Bruce E. Compas, PhD         
Sponsors and Collaborators
Vanderbilt University
National Institute of Mental Health (NIMH)
Principal Investigator: Bruce E. Compas, PhD Vanderbilt University
  More Information

Responsible Party: Bruce Compas, Patricia and Rodes Hart Professor, Vanderbilt University Identifier: NCT00183482     History of Changes
Other Study ID Numbers: R01MH069940 ( US NIH Grant/Contract Award Number )
Study First Received: September 13, 2005
Last Updated: April 11, 2017

Keywords provided by Vanderbilt University:

Additional relevant MeSH terms:
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders processed this record on May 22, 2017