The Influence of Psychological Interventions Upon Disease Progression in HIV-infected Patients Receiving no Medication
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|ClinicalTrials.gov Identifier: NCT00180700|
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : February 12, 2016
|Condition or disease||Intervention/treatment||Phase|
|HIV Infected Individuals||Behavioral: Self-hypnosis Behavioral: Johrei - a Japanese stress management system||Not Applicable|
Hypothesis: This investigation is based upon the hypothesis that psychological intervention may counteract the detrimental effects of stress both on psychological well-being and on general health.
Background: HIV infection may be considered to be a life-long biological and psychological stressor leading to detrimental outcomes associated with disease progression. Stress reduction in these patients may have beneficial effects through delaying disease progression via the proposed interactive psycho-neuro-endocrine-immune network.
HIV infected individuals CD4 T-cell counts above 200 cells/mcl Receiving no anti-retroviral drugs Individuals who signed the informed consent form
Investigative approach: Self-hypnosis and a Japanese non-touching, laying-on-of hands-like technique, called Johrei, were used to investigate the effects of psychological intervention upon immune parameters (especially in CD4 counts) associated with disease progression along with phenomenological associations between stress perception and stress hormone levels in HIV-infected patients receiving no medication.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||100 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||The Effects of Two Psychological Intervention Techniques, Self-hypnosis and Johrei Healing Method, on Quality of Life, Psychological Well-being, EEG Measures and Various Immunological Measures Including CD4+ Counts in Early HIV: a Randomly Controlled Pilot Study|
|Study Start Date :||June 2003|
|Study Completion Date :||December 2004|
- CD4 T-cell counts
- Other immunological parameters (Viral load levels, NK cell counts)
- Psychological questionnaires (Perceived Stress Scale (PSS), STAI, Beck depression Inventory (BDI))
- Endogenous hormone levels (cortisol, DHEA-S and melatonin)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00180700
|Imperial College London|
|London, England, United Kingdom, W6 8RP|
|Principal Investigator:||John H Gruzelier, Ph.D.||Imperial College London|
|Study Director:||Don C Henderson, Ph.D.||Imperial College London|