Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome

This study has been completed.
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
First received: September 12, 2005
Last updated: NA
Last verified: July 2004
History: No changes posted
Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus (SARS-CoV). The major clinical features of SARS include fever, dyspnea, lymphopenia, and a rapid progression of pulmonary infiltrates on chest radiologic images. The SARS-related deaths have resulted mainly from pulmonary complications, including progressive respiratory failure due to alveolar damage and acute respiratory distress syndrome (ARDS). Pathological changes in SARS suggest that SARS sequelae such as infiltration of PMN in lung tissue, multiple organ dysfunction and ARDS have been associated with cytokines and chemokine dysregulation. Some patients still manifested lung injury at a time when the viral load was falling also supports the immune nature of the lung damage. We therefore undertook an analysis of dynamic production of cytokine/chemokines in SARS patients with an initial normal chest radiograph in order to improve understanding of disease pathogenesis and improve patient management.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Longitudinal

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:


Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both

Inclusion Criteria:

  • SARS group: Patients with SARS

Exclusion Criteria:

  • Hospital acquired pneumonia
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00173459

Sponsors and Collaborators
National Taiwan University Hospital
Study Chair: Jung-Yien Chien, MD NTUH
  More Information

ClinicalTrials.gov Identifier: NCT00173459     History of Changes
Other Study ID Numbers: 9461700671 
Study First Received: September 12, 2005
Last Updated: September 12, 2005
Health Authority: Taiwan: Department of Health

Additional relevant MeSH terms:
Coronavirus Infections
Severe Acute Respiratory Syndrome
Coronaviridae Infections
Nidovirales Infections
RNA Virus Infections
Respiratory Tract Diseases
Respiratory Tract Infections
Virus Diseases

ClinicalTrials.gov processed this record on April 27, 2016