Mechanisms of Neuropathic Pain: Investigation by Contact Heat Evoked Potential

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00173420
Recruitment Status : Unknown
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : October 23, 2007
Information provided by:
National Taiwan University Hospital

Brief Summary:
In order to clarify the normal components of thermal and painful evoked potentials by heat in normal subjects of both genders and different age group, to clarify the effect of specific anatomy in pain transduction, transmission and modification, and to establish the effect of peripheral nerve and their terminal free ending on the nociceptive transduction, the investigators will use heat stimulation on normal controls and patients with neurological diseases to clarify such issues.

Condition or disease
Peripheral Nerve Diseases

Detailed Description:

Only a few studies focus on clinical diseases like neuropathic pain or neurogenic pain. Little is known about the differences between normal and pathogenic pain processing. It is an opportunity to apply EEG, ERPs in the clinical fields. In many clinical conditions, brain lesions provide a chance to study the possible roles of one neural structure in pain integration and processing. In addition the applications of EEG/ERPs on clinical conditions may be help in the understanding about mechanism and genesis of pain in pathogenic conditions, the diagnosis of pathogenic pain, and the therapeutic aspects of these abnormal pain senses.

One limit in the study of human pain is the inappropriate stimulation method. Evoked potentials by contact heat have previously been difficult to elicit due to slow temperature rise times associated with thermal stimulators. However recently, the CHEPS (Contact Heat-Evoked Potential Stimulator) is developed, which uses a newly developed heat-foil technology and can create a rapid heating rate (up to 70°C/sec). The baseline and peak temperature and the rising time can be precisely controlled. It provides a non-invasive technique in the investigation of human pain activation related to thermal and nociceptive pathways involved in pain processing. Unlike the heat stimulation delivered by laser, CHEPS can deliver noxious thermal stimuli repeatedly to a large area of skin to evoke a pain response of A-Delta and C fibers. In addition the rate of stimulation can be rapid to lead to the effect of temporal summation. When used with an EEG recording system, a patient's responses to pain perception and evoked potentials (EPs) can be recorded, which provide objective information about integrity of the nociceptive afferents of peripheral nerve system, spinal cord, as well as the brain response of different structures. The CHEPS provide the investigators a practical and convenient tool in clinical application to study pain. The investigators will use the CHEPS as stimulation for studying the heat evoked potentials and analyze the difference between the normal subjects and patients with peripheral nerve diseases. These might help to clarify the mechanism of neuropathic pain.

Study Type : Observational
Estimated Enrollment : 100 participants
Official Title: Mechanisms of Neuropathic Pain: Investigation by Contact Heat Evoked Potential
Study Start Date : June 2005

Information from the National Library of Medicine

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Ages Eligible for Study:   15 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Patients with peripheral nerve diseases or other neurological diseased with sensory disturbance
  • Normal subjects without:

    • Systemic disease like diabetes mellitus, renal disease or other systemic diseases
    • Abnormal neurological symptoms or signs
    • Psychological disease like affective disorders or psychosis.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00173420

Contact: Sung-Tsang Hsieh, PhD 886-2-23123456 ext 8182

Department of Anatomy and Cell Biology, National Taiwan University College of Medicine Recruiting
Taipei, Taiwan
Contact: Sung-Tsang Hsieh, PhD    886-2-23123456 ext 8182   
Sponsors and Collaborators
National Taiwan University Hospital
Study Director: Sung-Tsang Hsieh, PhD Department of Anatomy and Cell Biology, National Taiwan University College of Medicine; Department of Neurology, National Taiwan University Hospital. Identifier: NCT00173420     History of Changes
Other Study ID Numbers: 9461700654
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: October 23, 2007
Last Verified: June 2005

Keywords provided by National Taiwan University Hospital:
Normal Controls

Additional relevant MeSH terms:
Nervous System Diseases
Peripheral Nervous System Diseases
Neurologic Manifestations
Neuromuscular Diseases
Signs and Symptoms