Genetic Studies in Liver Cancer Patients
Recruitment status was: Recruiting
|Study Design:||Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective
|Official Title:||Identification of Differentially Expressed Genes in Hepatocellular Carcinoma With DNA Microarrays|
|Study Start Date:||January 2005|
The clinical samples will be collected in the NTUH, while the DNA microarray works will be done in Biomedical Engineering Center (BMEC) of ITRI.
Patients A total of 40 cases of HCC patients (20 HBV-related HCC and 20 HCV-related HCC) who received surgical resection in National Taiwan University Hospital will be enrolled from our tissue banks. The diagnosis of HCC was confirmed by pathological examination. The surgical specimens were frozen immediately after surgery and stored in –140°C. The clinicopathological data will be retrospectively obtained from chart reviews.
Another total of 40 new HCC patients who receive surgical resection in National Taiwan University Hospital will be collected. The healthy subjects and patients chronically infected with HBV or HCV without HCC will be used as controls. The whole bloods will be collected before, one and six months after operation. The diagnosis of HCC will be confirmed by pathology. In addition to the whole bloods, the surgical specimens will be frozen immediately after surgery and stored in –140°C.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00172640
|National Taiwan University Hospital|
|Taipei, Taiwan, 100|
|Principal Investigator:||Chien-Hung Chen, MD||National Taiwan University Hospital|