IL-7 Receptor Polymorphisms and Immune Recovery With HAART
|ClinicalTrials.gov Identifier: NCT00168207|
Recruitment Status : Completed
First Posted : September 15, 2005
Last Update Posted : January 20, 2012
|Condition or disease|
AIM: To examine the association between the four haplotypes of IL-7Rα gene and a cohort of HIV infected patients who have commenced HAART with varying CD4+ T lymphocyte responses.
METHODS: IL-7Rα gene SNPs and haplotypes will be measured by constructing DNA pools, and PCR amplification and DNA sequencing. IL-7Rα expression will be examined using constitutive expression of IL-7Rα, IL-7Rα gene expression, and inducible expression of IL7Rα.
|Study Type :||Observational|
|Actual Enrollment :||106 participants|
|Official Title:||The Relationship of Single Nucleotide Polymorphisms in the Interleukin-7 Receptor-α Gene to CD4+ Immune Recovery in HIV Infected Patients Who Begin Antiretroviral Treatment With HAART|
|Study Start Date :||May 2005|
|Actual Study Completion Date :||May 2009|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00168207
|The Alfred Hospital, Commercial Road|
|Melbourne, Victoria, Australia, 3004|
|Study Director:||Jennifer Hoy, A/Prof||The Alfred|
|Principal Investigator:||Sharon Lewin, Professor||Alfred Hospital, Melbourne, Vic 3004|