Community Intervention Trial for Youth (CITY) Study
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ClinicalTrials.gov Identifier: NCT00164580 |
Recruitment Status
:
Completed
First Posted
: September 14, 2005
Last Update Posted
: September 27, 2012
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
HIV Infections | Behavioral: Community-Level Intervention | Phase 2 Phase 3 |
In recent years, there have been increases in the rates of unprotected anal intercourse (UAI) reported by men who have sex with men (MSM) and in the numbers of newly diagnosed HIV infections among MSM. Surveys of young MSM (ages 15-29) in numerous U.S. cities from 1994-2000 found an HIV prevalence of 2.2% to 18%, however, HIV prevalence was higher among young MSM of color than among white men. In a survey of 23-29 year-old MSM,nearly 1/3 of African-American men and 15% of Hispanic/Latino men were infected with HIV.
The Community Intervention Trial for Youth (CITY) study is a 13-community randomized control trial designed to evaluate a multi-component, community-level intervention for MSM ages 15-25 (i.e., young MSM or YMSM). All 13 communities have some form of HIV-prevention activities naturally occurring in their jurisdiction, but 6 of the 13 communities were randomly assigned to also receive the multi-component intervention (1 additional city served as a case study and also received the intervention). This intervention includes 4 components: 1) community health advisor network (CHAN) consisting of YMSM who conduct outreach to their peers, including linking other YMSM to community services and conducting other parts of the intervention; 2) social marketing, to include the use media to disseminate HIV risk-reduction messages and promote positive norms for safer sex; 3) large group events with an HIV prevention theme; and 4) small group activities/workshops that focus on increasing HIV prevention skills and enhancing a positive self-identity.
The study population varies by site based on the specific racial or ethnic groups of YMSM that are targeted. African-American YMSM are the study population in Atlanta, Georgia (comparison site); Birmingham, Alabama (intervention site); and Chicago, Illinois (intervention site). Hispanic/Latino YMSM are the study population in Washington Heights/South Bronx, New York (intervention site); Jackson Heights/Queens, New York (comparison site); Orange County, California (intervention site); and San Gabriel Valley, California (comparison site). Asian and Pacific Islander YMSM are the study population in Seattle, Washington (intervention site) and San Diego, California (comparison site). YMSM regardless or race/ethnicity are the study population in Milwaukee, Wisconsin (intervention site); Detroit, Michigan (comparison site), Minneapolis, Minnesota (comparison site); and West Hollywood, California (intervention site).
The primary goals of the intervention are to 1) decrease UAI with any male partners; 2) decrease UAI with main male partners; and 3) decrease UAI with non-main (i.e., casual) male partners. Using a venue-based, time/space sampling strategy in each community, cross-sectional samples of YMSM were interviewed from May-August across 4 years (1999-2002). Data collected in 1999 and 2000 were prior to the implementation of the multi-component intervention, and data collected in 2001 and 2002 were during the implementation of the intervention.
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 12000 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Prevention of HIV Infection in Youth at Risk: Developing Community-Level Intervention Strategies That Work (Community Intervention Trial for Youth (CITY) Study) |
Study Start Date : | October 1996 |
Actual Primary Completion Date : | August 2002 |
Actual Study Completion Date : | August 2004 |

- 1) unprotected anal intercourse with a male partner in the past 3 months
- 2) unprotected anal intercourse at last sex with a main male partner (among participants with a male sex partner in the past 3 months and in the past year)
- 3) unprotected anal intercourse at last sex with the most recent non-main male partner (among participants with a male sex partner in the past 3 months and in the past year)

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Ages Eligible for Study: | 15 Years to 25 Years (Child, Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- 15-25 years of age
- reports having sexual contact with another man in the past year
- meets the race/ethnicity eligibility criteria for the particular community
Exclusion Criteria:

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00164580
United States, Alabama | |
University of Alabama - Birmingham | |
Birmingham, Alabama, United States, 35294 | |
United States, California | |
Childrens Hospital Los Angeles | |
Los Angeles, California, United States, 90027 | |
University of California-San Francisco, Center for AIDS Prevention Studies | |
San Francisco, California, United States, 94105 | |
United States, Georgia | |
Georgia State University | |
Atlanta, Georgia, United States, 30303 | |
United States, Illinois | |
University of Illinois at Chicago | |
Chicago, Illinois, United States, 60607 | |
United States, Massachusetts | |
Education Development Center | |
Newton, Massachusetts, United States, 02158 | |
United States, Minnesota | |
University of Minnesota Youth and AIDS Projects | |
Minneapolis, Minnesota, United States, 55403 | |
United States, Wisconsin | |
Medical College of Wisconsin, Center for AIDS Intervention Research | |
Milwaukee, Wisconsin, United States, 53202 |
Principal Investigator: | Carolyn A Guenther-Grey, M.A. | Centers for Disease Control and Prevention |
Publications:
Responsible Party: | Centers for Disease Control and Prevention |
ClinicalTrials.gov Identifier: | NCT00164580 History of Changes |
Other Study ID Numbers: |
CDC-NCHSTP-1733 U62/CCU113642 U62/CCU513631 U62/CCU513650 U62/CCU513661 U62/CCU913658 |
First Posted: | September 14, 2005 Key Record Dates |
Last Update Posted: | September 27, 2012 |
Last Verified: | September 2012 |
Keywords provided by Centers for Disease Control and Prevention:
Homosexuality, Male Adolescents Minority Groups Community Participation |
Community Surveys HIV Seronegativity HIV |
Additional relevant MeSH terms:
Infection HIV Infections Acquired Immunodeficiency Syndrome Lentivirus Infections Retroviridae Infections RNA Virus Infections |
Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases |