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Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2005 by Bayside Health.
Recruitment status was:  Recruiting
University of Adelaide
Information provided by:
Bayside Health Identifier:
First received: September 13, 2005
Last updated: July 31, 2007
Last verified: September 2005
The purpose of this study is to examine gene expression profiles by DNA microarray in patients who are responders and non-responders to interferon and ribavirin treatment for hepatitis C virus (HCV). Genes involved in inflammation and fibrosis and mediators of the Th-1 lymphocyte response will be looked for. It is hoped that genetic targets for future more effective and less toxic treatments will be identified.

Condition Intervention
Hepatitis C
Procedure: Liver biopsy

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection

Resource links provided by NLM:

Further study details as provided by Bayside Health:

Estimated Enrollment: 60
Study Start Date: February 2004
Estimated Study Completion Date: February 2007
  Show Detailed Description


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • HCV mono-infection, no coagulopathy and having a liver biopsy for consideration of treatment

Exclusion Criteria:

  • Infection with HIV or HBV, excess ethanol (EtOH) consumption and other diseases of the liver
  Contacts and Locations
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Please refer to this study by its identifier: NCT00164073

Contact: Mark D Berzsenyi, MBBS 0417 574 015

Australia, Victoria
Alfred Hospital Recruiting
Melbourne, Victoria, Australia, 3181
Contact: Mark D Berzsenyi, MBBS    0417 574 015   
Principal Investigator: Mark D Berzsenyi, MBBS         
Sponsors and Collaborators
Bayside Health
University of Adelaide
Principal Investigator: Mark D Berzsenyi, MBBS The Alfred
  More Information Identifier: NCT00164073     History of Changes
Other Study ID Numbers: 122/03
Study First Received: September 13, 2005
Last Updated: July 31, 2007

Keywords provided by Bayside Health:
HCV and microarray

Additional relevant MeSH terms:
Hepatitis A
Hepatitis C
Hepatitis, Chronic
Hepatitis C, Chronic
Virus Diseases
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Flaviviridae Infections
Antineoplastic Agents
Antiviral Agents
Anti-Infective Agents
Molecular Mechanisms of Pharmacological Action processed this record on May 25, 2017