Biomarkers of iNOS Activity in COPD, Asthma, Healthy Control
|ClinicalTrials.gov Identifier: NCT00159302|
Recruitment Status : Completed
First Posted : September 12, 2005
Last Update Posted : September 12, 2005
This pilot study will measure the baseline levels and the intra- and inter-subject variability of exhaled (alveolar and bronchial) and nasal NO in smoking subjects with mild and moderate COPD on or off steroid treatment, smoking healthy volunteers and non-smoking mild asthmatics off steroids, using multiple exhalation flow rates.
In addition, exploratory markers of iNOS activity (eg. 3-nitrotyrosine, nitrite, nitrate and 3-nitro-4-hydoxyphenylacetic acid) in blood, sputum, urine and exhaled breath condensate will be evaluated. We will also evaluate exhaled and nasal NO in a population of mild asthmatics in order to obtain baseline and variability data for future clinical studies involving asthmatic subjects.
|Condition or disease||Intervention/treatment|
|Healthy Smokers Healthy Non-Smokers Patients With Mild Asthma Patints With COPD (GOLD II)||Procedure: Induced Sputum Procedure: Exhaled Nitric Oxide Procedure: Nasal Nitric Oxide Procedure: Blood Tests Procedure: 24hr Urine Samples Procedure: Exhaled Breath Condensate Procedure: Spirometry|
|Study Type :||Observational|
|Estimated Enrollment :||36 participants|
|Observational Model:||Defined Population|
|Official Title:||A Pilot Study to Evaluate and Develop Biomarkers of iNOS Activity in Patients With COPD or Asthma and Healthy Volunteers|
|Study Start Date :||September 2003|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00159302
|Section of Airway Disease, Asthma Lab, Imperial College London, Royal Brompton Hospital|
|London, United Kingdom, SW3 6LY|
|Principal Investigator:||Sergei A Kharitonov, MD PhD||Imperial College London|