Analysis of Genetic Factors Which May Influence the Course of HIV Infection

This study has been completed.
Information provided by:
Hadassah Medical Organization Identifier:
First received: September 9, 2005
Last updated: June 22, 2011
Last verified: June 2010
Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.

HIV Infection

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms

Resource links provided by NLM:

Further study details as provided by Hadassah Medical Organization:

Biospecimen Retention:   Samples With DNA
DNA isolated from peripheral blood.

Estimated Enrollment: 150
Study Start Date: February 2004
Study Completion Date: April 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
Detailed Description:
Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections).

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with HIV attending the HIV clinic at Hadassah colden globes.

Inclusion Criteria:

  • diagnosis of HIV

Exclusion Criteria:

  • under 18 years of age
  Contacts and Locations
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Please refer to this study by its identifier: NCT00159068

Hadassah Medical Organization
Jerusalem, Israel, IL91120
Sponsors and Collaborators
Hadassah Medical Organization
Principal Investigator: Deborah Rund, MD Hadassah Medical Organization
  More Information

Responsible Party: Deborah Rund, Hadassah Medical Organization Identifier: NCT00159068     History of Changes
Other Study ID Numbers: 391200-HMO-CTIL 
Study First Received: September 9, 2005
Last Updated: June 22, 2011
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Additional relevant MeSH terms:
Acquired Immunodeficiency Syndrome
HIV Infections
Immune System Diseases
Immunologic Deficiency Syndromes
Lentivirus Infections
RNA Virus Infections
Retroviridae Infections
Sexually Transmitted Diseases
Sexually Transmitted Diseases, Viral
Slow Virus Diseases
Virus Diseases processed this record on May 26, 2016