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This is a study of how well caregivers of children with malaria adhere to the recommended regimen for lumefantrine-artemether (LA). Children were randomly assigned to either a group receiving directly observed treatment in hospital or to a group treated at home by the routine caregiver (typically, patient's mother). Clinical/parasitologic, hematologic, pharmacologic and qualitative parameters were monitored over a 28-day follow-up period and are used to evaluate drug adherence.
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Ages Eligible for Study:
up to 59 Months (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
age < 5 years of age.
axillary temperature >= 37.5oC
unmixed infection with P. falciparum of between 1,000 and 250,000 asexual parasites/mm3 as determined by microscopic examination of thick, or thick and thin peripheral blood smears.
parent/guardian's informed consent and willingness to participate in the study
any evidence of severe or complicated malaria that would require hospitalization for treatment.
reported allergy to any antimalarial drugs, including artemisinin derivatives and sulfa drugs.