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Cardiovascular Health Study (CHS) Events Follow-up Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00149435
Recruitment Status : Completed
First Posted : September 8, 2005
Last Update Posted : May 7, 2018
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Bruce Psaty, University of Washington

Brief Summary:
To support follow-up for the Cardiovascular Health Study (CHS) of coronary heart disease and stroke risk factors in adults 65 years or older.

Condition or disease
Cardiovascular Diseases Coronary Disease Cerebrovascular Accident Diabetes Mellitus Heart Diseases Hypertension Heart Failure, Congestive

Detailed Description:


The Cardiovascular Health Study (CHS) is an NHLBI-funded cohort study of risk factors for coronary heart disease (CHD) and stroke in adults 65 years or older. In the early 1990s, 5888 participants underwent examinations that included traditional risk factors and measures of sub-clinical disease. During follow-up, many exam components were repeated, and CVD events were ascertained. The National Heart, Lung, and Blood Institute has extended CHS contract funding (1) to implement a model for a transition from contract-funding to investigator-initiated research and (2) to enhance access to CHS data for future papers and ancillary studies by CHS and non-CHS colleagues. The Events Follow-up Study will provide a foundation for the transition. Current and future papers and ancillary studies using CHS data or stored specimens will have additional power and can be conducted more efficiently if a service events-core continues to collect and adjudicate CVD events and deaths in a standardized fashion.


Structurally, the primary aims are: (1) to evaluate the incidence rates of and risk factors for CVD in older adults, including comparisons between blacks and whites, men and women, young old and old; (2) the evaluation of prognosis in inception cohorts of older adults with new-onset conditions such as heart failure (HF) and atrial fibrillation; and (3) the evaluation of associations between risk-factor change and the incidence of subsequent events. Questions of interest include: What are the determinants of the low CHD incidence in women 80 yrs and older? Do older black women also have a low CHD incidence? What are the determinants of CHD, HF, and stroke in adults 80 and older? Are risk factors different between men and women, whites and blacks? Do traditional risk factors and measures of sub-clinical disease continue to be powerful predictors of CHD, HF and stroke in those 80 and older? In this study, the investigators expect to make over 20,000 phone calls to identify 6000 hospitalizations, 1000 deaths, 3000 events for detailed review, and 1500 new events, including 370 CHD, 300 stroke, and 450 HF. These new events represent an increase in the number of CVD events of 29% to 35% in whites and an increase of 40% to 49% in blacks. The data and specimens collected in CHS represent a major national resource for the study of health, aging, and cardiovascular disease in older adults. Additional events follow-up will not only provide the opportunity to address the aims of this study, but also enhance the power of current and future CHS papers and ancillary studies by CHS and non-CHS colleagues.

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Study Type : Observational
Actual Enrollment : 5888 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : September 2005
Actual Primary Completion Date : May 2009
Actual Study Completion Date : May 2009

Primary Outcome Measures :
  1. Cardiac health [ Time Frame: Annual ]
    Incidence of cardiac related death

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 100 Years   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
General population
No eligibility criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00149435

Sponsors and Collaborators
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)
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Study Director: Bruce Psaty University of Washington

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Bruce Psaty, Professor, Medicine and Epidemiology, University of Washington Identifier: NCT00149435     History of Changes
Other Study ID Numbers: 1295
5R01HL080295-07 ( U.S. NIH Grant/Contract )
First Posted: September 8, 2005    Key Record Dates
Last Update Posted: May 7, 2018
Last Verified: May 2018

Additional relevant MeSH terms:
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Diabetes Mellitus
Heart Failure
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases