Omega-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Severe Chronic Heart Failure
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Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Omega-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Severe Chronic Heart Failure:Effects On Endothelial Function, Left Ventricular Remodelling, Natriuretic Peptide Levels, And Exercise Capacity
Study Start Date
Actual Primary Completion Date
Actual Study Completion Date
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Chronic heart failure of non-ischemic origin
Age ≥18 years
NYHA functional class III-IV
LVEF < 35 %
Optimized heart failure therapy
plasma NT-BNP >2000pg/ml
Current treatment with Omacor or other fish oil products
Known hypersensitivity to the study drug
Uncorrected significant valvular heart disease
Heart failure due to congenital heart disease
Alcoholic heart disease
Continuous i.v. therapy for heart failure
Mechanical assist device
Life expectancy <1 year due to non-cardiac causes
Inability to perform bicycle testing
Women of childbearing potential not practicing a save contraception method
Current participation in another intervention study
Participation in another study with an intervention within the last 3 months.