Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering
|ClinicalTrials.gov Identifier: NCT00148161|
Recruitment Status : Unknown
Verified September 2006 by University Hospital Muenster.
Recruitment status was: Recruiting
First Posted : September 7, 2005
Last Update Posted : April 27, 2007
The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.
Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.
Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.
The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||20 participants|
|Observational Model:||Defined Population|
|Observational Model:||Natural History|
|Official Title:||Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering|
|Study Start Date :||November 2004|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00148161
|Contact: Antoinette G Dinnesen, Prof. Dr.||+49(0)251 83 ext firstname.lastname@example.org|
|Contact: Arne Knief, Dr.||+49(0)251 83 ext email@example.com|
|Institute for Biomagnetism and Biosignalanalysis||Recruiting|
|Münster, Germany, 48149|
|Contact: Christo Pantev, Prof. Dr. +49(0)251 83 ext 56865 firstname.lastname@example.org|
|Principal Investigator: Christo Pantev, Prof. Dr.|
|Department of Phoniatrics and Pediatric Audiology, University Hospital Münster||Recruiting|
|Münster, Germany, 48161|
|Contact: Antoinette G Dinnesen, Prof. Dr. +49(0)251 83 ext 56859 email@example.com|
|Principal Investigator: Antoinette G Dinnesen, Prof. Dr.|
|Principal Investigator: Arne Knief, Dr.|
|Sub-Investigator: Michael Schneider|
|Study Director:||Antoinette G Dinnesen, Prof. Dr.||Department of Phoniatrics and Pediatric Audiology, University Hospital Münster|
|Principal Investigator:||Arne Knief, Dr.||Department of Phoniatrics and Pediatric Audiology, University Hospital Münster|