Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion
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ClinicalTrials.gov Identifier: NCT00146926 |
Recruitment Status
: Unknown
Verified April 2007 by Hospices Civils de Lyon.
Recruitment status was: Active, not recruiting
First Posted
: September 7, 2005
Last Update Posted
: April 27, 2007
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Induction of Total Intravenous General Anesthesia | Drug: kétamine 20mg Drug: ephedrine 3mg Drug: lidocaine 40mg | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 200 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double |
Official Title: | Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion |
Study Start Date : | September 2005 |

- After prophylactic solution, evaluation of the pain caused by injection of propofol with a four-point scale before lose of consciousness
- Explicite and implicite memory of pain immediately after surgery and on day one
- Adverse effects

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Ages Eligible for Study: | 18 Years to 75 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Healthy adults (ASA 1-2) for scheduled surgery under general anesthesia with propofol
Exclusion Criteria:
- pregnant
- sedative or analgesic drug 24h before surgery
- allergy with drug used in the study
- difficulty of communication
- absence of informed written consent

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00146926
France | |
Grégoire CHATAIN | |
Lyon, France, 69495 |
Principal Investigator: | Vincent PIRIOU, MD | Hospices Civils de Lyon |
ClinicalTrials.gov Identifier: | NCT00146926 History of Changes |
Other Study ID Numbers: |
2004.367 |
First Posted: | September 7, 2005 Key Record Dates |
Last Update Posted: | April 27, 2007 |
Last Verified: | April 2007 |
Keywords provided by Hospices Civils de Lyon:
Propofol pain general anesthesia prevention |
Additional relevant MeSH terms:
Lidocaine Propofol Ketamine Ephedrine Anesthetics, Local Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Sensory System Agents Peripheral Nervous System Agents Anti-Arrhythmia Agents Voltage-Gated Sodium Channel Blockers Sodium Channel Blockers Membrane Transport Modulators |
Molecular Mechanisms of Pharmacological Action Hypnotics and Sedatives Anesthetics, Intravenous Anesthetics, General Analgesics Anesthetics, Dissociative Excitatory Amino Acid Antagonists Excitatory Amino Acid Agents Neurotransmitter Agents Central Nervous System Stimulants Sympathomimetics Autonomic Agents Vasoconstrictor Agents Adrenergic Agents |