The Effect of Isoflurane or Sevoflurane on Kidney Function

This study has been terminated.
Information provided by:
Austin Health Identifier:
First received: September 2, 2005
Last updated: NA
Last verified: August 2005
History: No changes posted
The purpose of this study is to determine if isoflurane and sevoflurane have similar effects on the kidneys of people with impaired kidneys when the drugs administered with low gas flow into anaesthetic machines.

Condition Intervention Phase
Kidney Failure
Drug: sevoflurane or isoflurane
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Bio-equivalence Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Post-Operative Creatinine Changes In Patients With Pre-Existing Renal Impairment After Low-Flow Isoflurane Or Sevoflurane: A Randomised Clinical Trial

Resource links provided by NLM:

Further study details as provided by Austin Health:

Primary Outcome Measures:
  • Change in creatinine in first three postoperative days

Estimated Enrollment: 270
Study Start Date: January 2002
Estimated Study Completion Date: August 2005
  Show Detailed Description


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

Adult patients for elective surgery who will:

  • Need to stay at least one night, and
  • Need general anaesthesia, and
  • Have a pre-operative serum creatinine concentration greater than 130 umol/l.

Exclusion Criteria:

  • The patient refuses.
  • The patient is less than 18 years of age.
  • The patient is on pre-operative dialysis
  • The anaesthetist plans to use only regional or total intravenous anaesthesia.
  • Specific types of surgery: craniotomy, carotid, and cardiac.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00144118

Australia, Victoria
Department of Anaesthesia, Austin Health
Melbourne, Victoria, Australia, 3084
Sponsors and Collaborators
Austin Health
Principal Investigator: David A Story, MD Department of Anaesthesia, Austin Health
  More Information Identifier: NCT00144118     History of Changes
Other Study ID Numbers: H2000/01072 
Study First Received: September 2, 2005
Last Updated: September 2, 2005
Health Authority: Australia: Department of Health and Ageing Therapeutic Goods Administration

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Diseases
Urologic Diseases
Anesthetics, General
Anesthetics, Inhalation
Central Nervous System Depressants
Physiological Effects of Drugs
Platelet Aggregation Inhibitors processed this record on May 26, 2016