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The Effect of Isoflurane or Sevoflurane on Kidney Function

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ClinicalTrials.gov Identifier: NCT00144118
Recruitment Status : Terminated
First Posted : September 5, 2005
Last Update Posted : September 5, 2005
Sponsor:
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to determine if isoflurane and sevoflurane have similar effects on the kidneys of people with impaired kidneys when the drugs administered with low gas flow into anaesthetic machines.

Condition or disease Intervention/treatment Phase
Kidney Failure Drug: sevoflurane or isoflurane Phase 4

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Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 270 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Post-Operative Creatinine Changes In Patients With Pre-Existing Renal Impairment After Low-Flow Isoflurane Or Sevoflurane: A Randomised Clinical Trial
Study Start Date : January 2002
Estimated Study Completion Date : August 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Creatinine
U.S. FDA Resources

Arms and Interventions


Outcome Measures

Primary Outcome Measures :
  1. Change in creatinine in first three postoperative days

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Adult patients for elective surgery who will:

  • Need to stay at least one night, and
  • Need general anaesthesia, and
  • Have a pre-operative serum creatinine concentration greater than 130 umol/l.

Exclusion Criteria:

  • The patient refuses.
  • The patient is less than 18 years of age.
  • The patient is on pre-operative dialysis
  • The anaesthetist plans to use only regional or total intravenous anaesthesia.
  • Specific types of surgery: craniotomy, carotid, and cardiac.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00144118


Locations
Australia, Victoria
Department of Anaesthesia, Austin Health
Melbourne, Victoria, Australia, 3084
Sponsors and Collaborators
Austin Health
Investigators
Principal Investigator: David A Story, MD Department of Anaesthesia, Austin Health
More Information

ClinicalTrials.gov Identifier: NCT00144118     History of Changes
Other Study ID Numbers: H2000/01072
First Posted: September 5, 2005    Key Record Dates
Last Update Posted: September 5, 2005
Last Verified: August 2005

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Diseases
Urologic Diseases
Sevoflurane
Isoflurane
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs