Study Evaluating ERB-041 With Methotrexate in Rheumatoid Arthritis
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The primary objective of this study is to compare the efficacy and safety of 3 dose levels of oral ERB-041 administered daily for 12 weeks versus placebo in subjects with active rheumatoid arthritis who have had a suboptimal response to therapy with stable doses of methotrexate (MTX).
Condition or disease
Drug: Methotrexate plus ERB-041 for 12 weeksDrug: Placebo for 12 weeks
A Randomized, Parallel, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of 3 Oral Doses of ERB-041 in Subjects With Rheumatoid Arthritis on a Background of Methotrexate Therapy
Study Start Date
Primary Completion Date
Study Completion Date
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Ages Eligible for Study:
18 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Clinical diagnosis of active rheumatoid arthritis for at least 6 months and on a stable dose of methotrexate for at least 12 weeks
Rheumatoid arthritis onset after 16 years of age
Any significant health problem other than rheumatoid arthritis
History of male or female reproductive system cancer