Creatine Treatment in Psychiatric Disorders
|ClinicalTrials.gov Identifier: NCT00140192|
Recruitment Status : Completed
First Posted : September 1, 2005
Last Update Posted : July 29, 2009
Creatine plays a pivotal role in brain energy homeostasis. Creatine supplementation is widely used in enhancing sports performance, and has been tried in the treatment of neurological, neuromuscular and atherosclerotic disease with a paucity of side effects.
Dechent et al (1999) studied the effect of oral creatine supplementation for 4 wk demonstrating a statistically significant increase of mean concentration of total creatine across brain regions. These findings suggest the possibility of using oral creatine supplementation to modify brain high-energy phosphate metabolism in subjects with various brain disorders, including schizophrenia and major depression. Recently, Rae et al (2003) reported that creatine supplementation for 6 weeks had a significant positive effect on both working memory and Raven matrices. Several independent lines of evidence suggest the possible involvement of altered cerebral energy metabolism in schizophrenia.
We are performing a double blind cross-over study of creatine in schizophrenia.
Forty patients will be treated with creatine for 3 months in a double-blind crossover design. Rating scales will include scales for assessing negative and positive symptoms of schizophrenia, clinical global impressions scale, scales for side-effects and a cognitive battery
Creatine effects on brain energy metabolism and its possible cognitive enhancing properties raise the possibility of developing a new therapeutic strategy in schizophrenia focusing on treating metabolic hypoactive brain areas including frontal regions.
|Condition or disease||Intervention/treatment||Phase|
|Schizophrenia||Drug: creatine||Phase 3|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||Creatine as a New Treatment for Schizophrenia:A Double-Blind Trial|
|Study Start Date :||September 2004|
|Actual Primary Completion Date :||March 2006|
|Actual Study Completion Date :||March 2006|
- Positive and Negative Syndrome Scale
- Clincal Global Impression
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00140192
|Beersheva Mental Health Center|
|Study Director:||RH Belmaker, MD||Ben Gurion University of the Negev + Beersheva Mental Health Center|