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A Study to Explore the Association Between Blood Pressure, HIV and Antiretroviral Therapy

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ClinicalTrials.gov Identifier: NCT00131807
Recruitment Status : Completed
First Posted : August 19, 2005
Last Update Posted : May 28, 2015
Sponsor:
Collaborator:
The Hypertension Trust
Information provided by:
Imperial College London

Brief Summary:
The purpose of this study is to explore the association between blood pressure, HIV and/or its treatment in a cross sectional observational study.

Condition or disease Intervention/treatment
HIV Infections Procedure: Blood Pressure Measurement Procedure: Questionnaire

Detailed Description:
Deaths from AIDS have declined dramatically since the introduction of highly active antiretroviral therapy in HIV infected patients. However the incidence of heart disease has increased four-fold and is now one of the major causes of death in HIV infected patients. While HIV drugs are known to adversely affect serum lipids, the evidence concerning the association between raised blood pressure (a major risk for cardiovascular disease) HIV and/or its treatment is limited and conflicting. The researchers believe it of interest to study heart disease risk factors in patients with HIV infection to avoid one premature cause of death (AIDS) being replaced with another potentially preventable cause of death and disability (heart disease). In this cross sectional observational study the researchers will systematically measure blood pressure and other cardiovascular risk factors in HIV positive patients on and off antiretroviral therapy. These individuals will be matched for age, sex and ethnic group with HIV negative individuals.

Study Type : Observational
Estimated Enrollment : 3000 participants
Time Perspective: Prospective
Official Title: A Study to Explore the Association Between Blood Pressure, HIV and Antiretroviral Therapy
Study Start Date : September 2005
Study Completion Date : September 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: HIV/AIDS
U.S. FDA Resources





Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Attending St. Mary's sexual health outpatient department
  • Patients willing to give written informed consent
  • Ability to communicate in English

Exclusion Criteria:

  • Failure to give written informed consent in English

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00131807


Locations
United Kingdom
St. Mary's Hospital
Paddington, London, United Kingdom, W2 1NY
Sponsors and Collaborators
Imperial College London
The Hypertension Trust
Investigators
Principal Investigator: Neil R Poulter Imperial College London

ClinicalTrials.gov Identifier: NCT00131807     History of Changes
Other Study ID Numbers: NPSW03
First Posted: August 19, 2005    Key Record Dates
Last Update Posted: May 28, 2015
Last Verified: April 2007

Keywords provided by Imperial College London:
Blood Pressure
HIV
Antiretroviral therapy

Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases