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Effect of Glutathione on Blood Alcohol and Hangover Symptoms

This study has been completed.
T.C Union Global Plc.
Information provided by:
Piyavate Hospital Identifier:
First received: August 4, 2005
Last updated: August 23, 2005
Last verified: July 2005

Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant.

As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and excretes in urine as mercapturic acid.

In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing effect.

The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a correlation with hangover symptoms. This study is designed to find this correlation using blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the Slutske et al study.

Condition Intervention
Alcohol Drinking Drug: Glutathione

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Piyavate Hospital:

Estimated Enrollment: 100
Study Start Date: June 2005
Estimated Study Completion Date: August 2005
  Show Detailed Description


Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy
  • Males 20-40 years old
  • No allergies to alcohol

Exclusion Criteria:

  • Chronic disease
  • Increase in hepatic enzyme SGPT
  • Impending danger
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00127309

Piyavate Hospital
Bangkok, Thailand, 10320
Sponsors and Collaborators
Piyavate Hospital
T.C Union Global Plc.
Principal Investigator: Staporn Jinaratana, M.D Piyavate Hospital
  More Information

L. Casciani et al.,Effect of GSH on hepatic triglyceride levels at different times after ethanol intoxification IRSC Med.Sci.,vol.14,158(1986) Identifier: NCT00127309     History of Changes
Other Study ID Numbers: sj_1
Study First Received: August 4, 2005
Last Updated: August 23, 2005

Keywords provided by Piyavate Hospital:
hangover symptoms

Additional relevant MeSH terms:
Alcohol Drinking
Drinking Behavior processed this record on August 17, 2017