Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood
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|ClinicalTrials.gov Identifier: NCT00116311|
Recruitment Status : Unknown
Verified March 2007 by Groningen Research Institute for Asthma and COPD.
Recruitment status was: Active, not recruiting
First Posted : June 29, 2005
Last Update Posted : March 21, 2007
The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased adenosine receptor expression versus control subjects.
We also want to study the effects of allergen inhalation on adenosine receptor expression in asthmatics. We believe that adenosine receptor expression will be upregulated after allergen inhalation.
Both hypotheses are being tested in sputum and peripheral blood.
|Condition or disease||Intervention/treatment|
|Asthma Healthy||Behavioral: allergen inhalation Behavioral: withdrawal of medication Procedure: sputum induction|
|Study Type :||Observational|
|Enrollment :||20 participants|
|Observational Model:||Defined Population|
|Official Title:||Effects of Allergen Inhalation on Adenosine Receptor Expression and Mast Cell Activation in Peripheral Blood and Sputum of Asthmatics and Healthy Subjects|
|Study Start Date :||July 2005|
|Study Completion Date :||February 2007|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00116311
|University Medical Center Groningen, Department of Pulmonology|
|Groningen, Netherlands, 9713 GZ|
|Principal Investigator:||Dirkje S Postma, prof. MD PhD||University Medical Center Groningen, Department of Pulmonology, hanzeplein 1, 9713 GZ Groningen, The Netherlands|