Oral Vitamin B12 Supplementation and Cognitive Performance in Elderly People
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00111267|
Recruitment Status : Completed
First Posted : May 19, 2005
Last Update Posted : June 24, 2005
|Condition or disease||Intervention/treatment||Phase|
|Cognitive Decline Cognitive Symptoms||Behavioral: vitamin B12 supplementation Behavioral: vitamin B12 + folic acid combined supplementation||Not Applicable|
Mild vitamin B12 deficiency is highly prevalent in old age. Reasons for this high prevalence are not fully understood, but include atrophic gastritis and bacterial overgrowth which affect the absorption (active) of food-bound vitamin B12. In contrast, the ability to absorb crystalline vitamin B12 (e.g. the form found in fortified foods or vitamin pills) remains intact in old age. In both healthy and cognitively impaired elderly people, associations between vitamin B12 status and cognitive performance have been observed, and the follow-up of geriatric patients suggests effects of parenteral treatment in early cognitive impairment.
We investigated whether daily oral supplementation with 1,000 μg vitamin B12 or 1,000 μg vitamin B12 combined with 400 μg folate for 24 weeks improves cognitive performance in people over 70 years with vitamin B12 deficiency.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||165 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||The Effect of Oral Vitamin B12 Supplementation on Cognitive Performance in Elderly People: the Brain12 Study|
|Study Start Date :||May 2003|
|Study Completion Date :||January 2005|
- Cognitive performance in the domains of attention, concentration, memory, executive function, speed
- Blood biochemistry including vitamin B12, methylmalonic acid, holotranscobalamin, homocysteine, and red blood cell folate
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00111267
|Wageningen, Gelderland, Netherlands, 6700 EV|